West Nile virus: an update on pathobiology, epidemiology, diagnostics, control and “one health” implications

G Habarugira, WW Suen, J Hobson-Peters, RA Hall… - Pathogens, 2020 - mdpi.com
West Nile virus (WNV) is an important zoonotic flavivirus responsible for mild fever to severe,
lethal neuroinvasive disease in humans, horses, birds, and other wildlife species. Since its …

Chimeric vaccines based on novel insect-specific flaviviruses

JJ Harrison, J Hobson-Peters, H Bielefeldt-Ohmann… - Vaccines, 2021 - mdpi.com
Vector-borne flaviviruses are responsible for nearly half a billion human infections
worldwide each year, resulting in millions of cases of debilitating and severe diseases and …

Neuroinvasiveness of the MR766 strain of Zika virus in IFNAR-/- mice maps to prM residues conserved amongst African genotype viruses

E Nakayama, F Kato, S Tajima, S Ogawa, K Yan… - PLoS …, 2021 - journals.plos.org
Zika virus (ZIKV) strains are classified into the African and Asian genotypes. The higher
virulence of the African MR766 strain, which has been used extensively in ZIKV research, in …

Replication is the key barrier during the dual-host adaptation of mosquito-borne flaviviruses

Y Zhang, D Liang, F Yuan, Y Yan… - Proceedings of the …, 2022 - National Acad Sciences
Mosquito-borne flaviviruses (MBFs) adapt to a dual-host transmission circle between
mosquitoes and vertebrates. Dual-host affiliated insect-specific flaviviruses (dISFs) …

Antigenic characterization of new lineage II insect-specific flaviviruses in Australian mosquitoes and identification of host restriction factors

JJ Harrison, J Hobson-Peters, AMG Colmant, J Koh… - Msphere, 2020 - Am Soc Microbiol
We describe two new insect-specific flaviviruses (ISFs) isolated from mosquitoes in
Australia, Binjari virus (BinJV) and Hidden Valley virus (HVV), that grow efficiently in …

Understanding the mechanisms underlying host restriction of insect-specific viruses

AME Elrefaey, R Abdelnabi, AL Rosales Rosas… - Viruses, 2020 - mdpi.com
Arthropod-borne viruses contribute significantly to global mortality and morbidity in humans
and animals. These viruses are mainly transmitted between susceptible vertebrate hosts by …

Insect-specific flavivirus replication in mammalian cells is inhibited by physiological temperature and the zinc-finger antiviral protein

AMG Colmant, J Hobson-Peters, TAP Slijkerman… - Viruses, 2021 - mdpi.com
The genus Flavivirus contains pathogenic vertebrate-infecting flaviviruses (VIFs) and insect-
specific flaviviruses (ISF). ISF transmission to vertebrates is inhibited at multiple stages of the …

Evidence of Infection with Zoonotic Mosquito-Borne Flaviviruses in Saltwater Crocodiles (Crocodylus porosus) in Northern Australia

G Habarugira, J Moran, JJ Harrison, SR Isberg… - Viruses, 2022 - mdpi.com
The risk of flavivirus infections among the crocodilian species was not recognised until West
Nile virus (WNV) was introduced into the Americas. The first outbreaks caused death and …

[HTML][HTML] Stay-at-home orders are associated with emergence of novel SARS-CoV-2 variants

RA Zimerman, FA Cadegiani, RAP e Costa, A Goren… - Cureus, 2021 - ncbi.nlm.nih.gov
Background While public health strategies to contain the current coronavirus disease 2019
(COVID-19) pandemic are primarily focused on social distancing and isolation, emerging …

Improved detection of flaviviruses in Australian mosquito populations via replicative intermediates

CA O'Brien, JJ Harrison… - Journal of General …, 2021 - microbiologyresearch.org
Mosquito-borne flaviviruses are significant contributors to the arboviral disease burdens
both in Australia and globally. While routine arbovirus surveillance remains a vital exercise …