Analgesic effect of acetaminophen: a review of known and novel mechanisms of action
N Ohashi, T Kohno - Frontiers in Pharmacology, 2020 - frontiersin.org
Acetaminophen is one of the most commonly used analgesic agents for treating acute and
chronic pain. However, its metabolism is complex, and its analgesic mechanisms have not …
chronic pain. However, its metabolism is complex, and its analgesic mechanisms have not …
[图书][B] Pharmacological actions of cannabinoids
RG Pertwee - 2005 - Springer
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SpringerLink Account Menu Find a journal Publish with us Track your research Search Cart …
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not
The development of antagonists of the transient receptor potential vanilloid-1 (TRPV1)
channel as pain therapeutics has revealed that these compounds cause hyperthermia in …
channel as pain therapeutics has revealed that these compounds cause hyperthermia in …
Mechanisms of endocannabinoid control of synaptic plasticity
BL Winters, CW Vaughan - Neuropharmacology, 2021 - Elsevier
The endogenous cannabinoid transmitter system regulates synaptic transmission
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …
throughout the nervous system. Unlike conventional transmitters, specific stimuli induce …
TRPV1 in the central nervous system: synaptic plasticity, function, and pharmacological implications
JG Edwards - Capsaicin as a therapeutic molecule, 2014 - Springer
The function of TRPV1 in the peripheral nervous system is increasingly being investigated
for its anti-inflammatory and antinociceptive properties in an effort to find a novel target to …
for its anti-inflammatory and antinociceptive properties in an effort to find a novel target to …
Modulation of trigeminal sensory neuron activity by the dual cannabinoid–vanilloid agonists anandamide, N‐arachidonoyl‐dopamine and arachidonyl‐2 …
TJ Price, A Patwardhan, AN Akopian… - British journal of …, 2004 - Wiley Online Library
Peripheral cannabinoids have been shown to suppress nociceptive neurotransmission in a
number of behavioral and neurophysiological studies. It is not known, however, whether …
number of behavioral and neurophysiological studies. It is not known, however, whether …
Anandamide and the vanilloid receptor (TRPV1)
Arachidonylethanolamide (anandamide) was identified some 15 years ago as a brain
constituent that binds to the cannabinoid receptor. After this seminal discovery, multiple new …
constituent that binds to the cannabinoid receptor. After this seminal discovery, multiple new …
Preclinical studies of posttraumatic headache and the potential therapeutics
M Tanaka, Y Zhang - Cells, 2022 - mdpi.com
Posttraumatic headache (PTH) attributed to traumatic brain injury (TBI) is a secondary
headache developed within 7 days after head injury, and in a substantial number of patients …
headache developed within 7 days after head injury, and in a substantial number of patients …
Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids
A Telleria-Diaz, M Schmidt, S Kreusch, AK Neubert… - Pain, 2010 - journals.lww.com
Abstract Both cyclooxygenase-1 and-2 are expressed in the spinal cord, and the spinal COX
product prostaglandin E 2 (PGE 2) contributes to the generation of central sensitization upon …
product prostaglandin E 2 (PGE 2) contributes to the generation of central sensitization upon …
Retrograde signalling by endocannabinoids
CW Vaughan, MJ Christie - Cannabinoids, 2005 - Springer
The cannabinoid neurotransmitter system comprises cannabinoid G protein-coupled
membrane receptors (CB 1 and CB 2), endogenous cannabinoids (endocannabinoids), as …
membrane receptors (CB 1 and CB 2), endogenous cannabinoids (endocannabinoids), as …