Pepper originated from the Capsicum genus, which is recognized as one of the most
predominant and globally distributed genera of the Solanaceae family. It is a diverse genus …

Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …

There is persuasive epidemiological and experimental evidence that dietary phytochemicals
have anticancer activity. Capsaicin is a bioactive phytochemical abundant in red and chili …

Breast cancer is the most common cancer among females worldwide. Several
epidemiological studies suggested the inverse correlation between the intake of vegetables …

Capsaicinoids are plant secondary metabolites, capsaicin being the principal responsible
for the pungency of chili peppers. It is biosynthesized through two pathways involved in …

The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a
transmembrane protein that can be activated by various physical and chemical stimuli and is …

Nanomedicine have shown success in cancer therapy, but the pharmacological actions of
most nanomedicine are often nonspecific to cancer cells because of utilization of the …

An increasing number of studies show that the activation of the innate immune system and
inflammatory mechanisms play an important role in the pathogenesis of numerous diseases …

Human exposure to capsaicin, the most abundant pungent chili pepper component, is
ubiquitous. Evaluation of capsaicin's carcinogenic potential has produced variable results in …

Chronic pain is a common symptom experienced during cancer progression. Additionally,
some patients experience bone pain caused by cancer metastasis, which further …