Aging is associated with a progressive loss of muscle mass and strength and a decline in
neurophysiological functions. Age-related neuromuscular junction (NMJ) plays a key role in …

Bassoon and Piccolo are two very large scaffolding proteins of the cytomatrix assembled at
the active zone (CAZ) where neurotransmitter is released. They share regions of high …

Physical inactivity (PI) is a major risk factor of chronic diseases. A major aspect of PI is loss
of muscle mass and strength. The latter phenomenon significantly impacts daily life and …

The escalation of life expectancy is accompanied by an increase in the prevalence of age-
related conditions, such as sarcopenia. Sarcopenia, a muscle condition defined by low …

Physical activity plays an important role in preventing chronic disease in adults and the
elderly. Exercise has beneficial effects on the nervous system, including at the …

Impaired synaptic plasticity is implicated in the functional decline of the nervous system
associated with ageing. Understanding the structure of ageing synapses is essential to …

Voltage‐gated calcium (CaV) channels and their regulation by proteins at the synaptic cleft
play a critical role in neurotransmission. These interactions fine‐tune the synaptic response …

The synapse between motor neurons and skeletal muscle is known as the neuromuscular
junction (NMJ). Proper alignment of presynaptic and post-synaptic structures of motor …

Aging is a one-way process associated with profound structural and functional changes in
the organism. Indeed, the neuromuscular system undergoes a wide remodeling, which …

Transactive response DNA‐binding protein‐43 (TDP‐43) is involved in gene regulation via
the control of RNA transcription, splicing, and transport. TDP‐43 is a major protein …