Clear cell renal cell carcinoma (ccRCC) is the most frequent histological kidney cancer
subtype. Over the last decade, significant progress has been made in identifying the genetic …

Aromatase inhibitors (AIs) are one of the principal therapeutic approaches for estrogen
receptor-positive (ER+) breast cancer in postmenopausal women. They block estrogen …

The androgen receptor (AR) is expressed in the majority of breast cancer and across the
three main breast cancer subtypes. Historically, the oncogenic role of AR has best been …

Purpose: Consensus is lacking regarding the androgen receptor (AR) as a prognostic
marker in breast cancer. The objectives of this study were to comprehensively review the …

Breast and prostate cancers are malignancies in which steroid hormones drive cellular
proliferation. Over the past century, this understanding has led to successful treatment …

Background Elucidating the unique immunoregulatory mechanisms in breast cancer
microenvironment may help develop new therapeutic strategies. Some studies have …

Breast cancer, an emerging disease among the women population, occurs due to
overexpression of estrogens. The enzyme aromatase plays a key rate limiting role in the …

The significance of androgen receptor (AR) in breast cancer (BC) management is not fully
defined, and it is still ambiguous how the level of AR expression influences oestrogen …

Androgen receptor (AR) is the most widely expressed steroid receptor protein in normal
breast tissue and is detectable in approximately 90% of primary breast cancers and 75% of …

Tamoxifen (Tam) resistance represents a significant clinical problem in estrogen receptor
(ER) α-positive breast cancer. We previously showed that decreased expression of Rho …