Relationship between clone metrics and clinical outcome in clonal cytopenia
Clonal cytopenia of undetermined significance (CCUS) is associated with an increased risk
of developing a myeloid neoplasm with myelodysplasia (MN). To identify the features of the …
of developing a myeloid neoplasm with myelodysplasia (MN). To identify the features of the …
Moving toward a conceptualization of measurable residual disease in myelodysplastic syndromes
Approximately 90% of patients with myelodysplastic syndromes (MDSs) have somatic
mutations that are known or suspected to be oncogenic in the malignant cells. The genetic …
mutations that are known or suspected to be oncogenic in the malignant cells. The genetic …
Endothelial cells: major players in acute myeloid leukaemia
S Fodil, M Arnaud, C Vaganay, A Puissant, E Lengline… - Blood Reviews, 2022 - Elsevier
The role of the vascular microenvironment is increasingly studied in acute myeloid
leukaemia (AML). Complex interactions between endothelial cells (ECs) and pre-leukaemic …
leukaemia (AML). Complex interactions between endothelial cells (ECs) and pre-leukaemic …
Paralog-specific signaling by IRAK1/4 maintains MyD88-independent functions in MDS/AML
Dysregulation of innate immune signaling is a hallmark of hematologic malignancies.
Recent therapeutic efforts to subvert aberrant innate immune signaling in myelodysplastic …
Recent therapeutic efforts to subvert aberrant innate immune signaling in myelodysplastic …
Leukemic stem cell: a mini-review on clinical perspectives
IV Barreto, FMCP Pessoa, CB Machado… - Frontiers in …, 2022 - frontiersin.org
Hematopoietic stem cells (HSCs) are known for their ability to proliferate and self-renew,
thus being responsible for sustaining the hematopoietic system and residing in the bone …
thus being responsible for sustaining the hematopoietic system and residing in the bone …
Detection of Cancer Stem Cells in Normal and Dysplastic/Leukemic Human Blood
A De Stefano, A Cappellini, I Casalin, S Paolini… - Cancer Stem Cells …, 2024 - Springer
The hierarchical organization of the leukemic stem cells (LSCs) is identical to that of healthy
counterpart cells. It may be split into roughly three stages: a small number of pluripotent stem …
counterpart cells. It may be split into roughly three stages: a small number of pluripotent stem …
Genetic heterogeneity in chronic myeloid leukemia: how clonal hematopoiesis and clonal evolution may influence prognosis, treatment outcome, and risk of …
E Sant'Antonio, C Camerini, V Rizzo, C Musolino… - … Myeloma and Leukemia, 2021 - Elsevier
Chronic myeloid leukemia (CML) has long been considered as a model of cancer caused by
a single-driver genetic lesion (BCR/ABL1 rearrangement) that codes for a unique, gain-of …
a single-driver genetic lesion (BCR/ABL1 rearrangement) that codes for a unique, gain-of …
Haematopoietic stem cell numbers are not solely determined by niche availability
Haematopoietic stem cells (HSCs) reside in specialized microenvironments, also referred to
as niches, and it has been widely believed that HSC numbers are determined by the niche …
as niches, and it has been widely believed that HSC numbers are determined by the niche …
Dynamic intestinal stem cell and mucosal remodeling by a mouse diet uniquely relevant to human risk and tumorigenesis
Background and Aims NWD1 is a purified rodent diet unique in establishing mouse
exposure to key nutrients recapitulating levels in the human that increase risk for intestinal …
exposure to key nutrients recapitulating levels in the human that increase risk for intestinal …
Les mutations d'IDH2 dans la leucémie aigue myéloïde confèrent une sensibilité spécifique à l'inhibition du métabolisme des acides aminés branchés (BCAA)
M Heiblig - 2022 - theses.hal.science
La leucémie aiguë myéloïde (LAM) est une maladie complexe et hétérogène sur le plan
moléculaire qui se caractérise par l'accumulation de progéniteurs myéloïdes immatures. Les …
moléculaire qui se caractérise par l'accumulation de progéniteurs myéloïdes immatures. Les …