HOX genes encode a family of evolutionarily conserved homeodomain transcription factors
that are crucial both during development and adult life. In humans, 39 HOX genes are …

Stem cells display a unique cell type within the body that has the capacity to self-renew and
differentiate into specialized cell types. Compared to pluripotent stem cells, adult stem cells …

Hox proteins are homeodomain transcription factors that diversify serially homologous
segments along the animal body axis, as revealed by the classic bithorax phenotype of …

In eukaryotes, members of transcription factor families often exhibit similar DNA binding
properties in vitro, yet orchestrate paralog-specific gene regulatory networks in vivo. The …

MADS-domain transcription factors are involved in the control of a multitude of processes in
eukaryotes, and in plants, they play particularly important roles during reproductive …

Hox proteins have similar binding specificities in vitro, yet they control different morphologies
in vivo. This paradox has been partially solved with the identification of Hox low-affinity …

The Trojan exon method, which makes use of intronically inserted T2A-Gal4 cassettes, has
been widely used in Drosophila to create thousands of gene-specific Gal4 driver lines …

The forewings and hindwings of butterflies and moths (Lepidoptera) are differentiated from
each other, with segment-specific morphologies and color patterns that mediate a wide …

Hox genes are known for their role in the specification of typical body plan features in
animals. Evolutionary changes in Hox gene function are believed to be involved in the …

Since their discovery, the Hox genes, with their incredible power to reprogram the identity of
complete body regions, a phenomenon called homeosis, have captured the fascination of …