Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Circadian clocks coordinate physiology and behavior with the 24h solar day to provide
temporal homeostasis with the external environment. The molecular clocks that drive these …

The circadian clock in mammals is driven by an autoregulatory transcriptional feedback
mechanism that takes approximately 24 hours to complete. A key component of this …

Mammalian basic HLH (helix–loop–helix)–PER–ARNT–SIM (bHLH–PAS) proteins are
heterodimeric transcription factors that sense and respond to environmental signals (such as …

From cyanobacteria to mammals, organisms have evolved timing mechanisms to adapt to
environmental changes in order to optimize survival and improve fitness. To anticipate these …

The circadian clock is an intracellular timekeeping device that drives daily rhythms in diverse
and extensive processes throughout the body. The clock mechanism comprises a core …

Drosophila cryptochrome (dCRY) is a FAD-dependent circadian photoreceptor, whereas
mammalian cryptochromes (CRY1/2) are integral clock components that repress …

Period (PER) proteins are essential components of the mammalian circadian clock. They
form complexes with cryptochromes (CRY), which negatively regulate CLOCK/BMAL1 …

There is increasing evidence that the core clock gene Period 1 (PER1) plays important roles
in the formation of various tumors. However, the biological functions and mechanism of …

Circadian oscillators are networks of biochemical feedback loops that generate 24-hour
rhythms in organisms from bacteria to animals. These periodic rhythms result from a …