Prevalence of peri-intubation major adverse events among critically ill patients: A systematic review and meta analysis

J Downing, I Yardi, C Ren, S Cardona, M Zahid… - The American Journal of …, 2023 - Elsevier
Background Peri-intubation major adverse events (MAEs) are potentially preventable and
associated with poor patient outcomes. Critically ill patients intubated in Emergency …

Malignant hyperthermia update

H Ellinas, MA Albrecht - Anesthesiology clinics, 2020 - anesthesiology.theclinics.com
After many years of uncertainty, malignant hyperthermia (MH) was eventually confirmed as a
human disease in 3 descendants by in vitro muscle biopsy. A 21-year-old engineering …

Association of propofol induction dose and severe pre-incision hypotension among surgical patients over age 65

RB Schonberger, F Dai, G Michel, MT Vaughn… - Journal of clinical …, 2022 - Elsevier
Study objective We aimed to study the association between propofol induction dose (mg/kg)
and pre-incision severe hypotension (Mean Arterial Pressure (MAP)≤ 55 mmHg) among …

[HTML][HTML] Availability of dantrolene for the management of malignant hyperthermia crises: European Malignant Hyperthermia Group guidelines

KPE Glahn, D Bendixen, T Girard, PM Hopkins… - British journal of …, 2020 - Elsevier
Faced with a malignant hyperthermia crisis, the immediate access to sufficient dantrolene is
essential to achieve the best possible outcome for the patient. However, malignant …

[HTML][HTML] Supramolecular therapeutics to treat the side effects induced by a depolarizing neuromuscular blocking agent

X Zhang, Q Cheng, L Li, L Shangguan, C Li, S Li… - Theranostics, 2019 - ncbi.nlm.nih.gov
Succinylcholine (Sch) is the only depolarizing neuromuscular blocking agent widely used for
rapid sequence induction in emergency rooms. Unfortunately, a variety of (sometimes lethal) …

Malignant Hyperthermia in PICU—From Diagnosis to Treatment in the Light of Up-to-Date Knowledge

M Klincová, D Štěpánková, I Schröderová… - Children, 2022 - mdpi.com
Malignant Hyperthermia (MH) is a rare, hereditary, life-threatening disease triggered by
volatile anesthetics and succinylcholine. Rarely, MH can occur after non-pharmacological …

Epidemiological and clinical features of malignant hyperthermia: A scoping review

Z Cong, T Wan, J Wang, L Feng, C Cao, Z Li… - Clinical …, 2024 - Wiley Online Library
Malignant hyperthermia (MH) is a potentially fatal inherited pharmacogenetic disorder
related to pathogenic variants in the RYR1, CACNA1S, or STAC3 genes. Early recognition …

[HTML][HTML] Succinylcholine and postoperative pulmonary complications: a retrospective cohort study using registry data from two hospital networks

MS Schaefer, M Hammer, P Santer, SD Grabitz… - British Journal of …, 2020 - Elsevier
Abstract Background Neuromuscular blocking agents (NMBAs) with a non-depolarising
mechanism of action carry the risk of postoperative residual paralysis and are associated …

Current practices in pharmacogenomics

LB Ramsey, CA Prows, ST Girdwood… - Pediatric …, 2023 - pediatric.theclinics.com
When choosing medications and calculating doses in infants, children, and adolescents, it is
common to consider the patient's diagnosis, age, weight, and sometimes body surface area …

Variation in propofol induction doses administered to surgical patients over age 65

RB Schonberger, A Bardia, F Dai… - Journal of the …, 2021 - Wiley Online Library
Abstract Background/Objectives Advanced age is associated with increased susceptibility to
acute adverse effects of propofol. The present study aimed to describe patterns of propofol …