The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease

LA Díaz, JP Arab, A Louvet, R Bataller… - Nature Reviews …, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD) are the
leading causes of chronic liver disease worldwide. NAFLD and ALD share …

The immunology of hepatocellular carcinoma

M Ringelhan, D Pfister, T O'Connor, E Pikarsky… - Nature …, 2018 - nature.com
In contrast to most other malignancies, hepatocellular carcinoma (HCC), which accounts for
approximately 90% of primary liver cancers, arises almost exclusively in the setting of …

EASL Clinical Practice Guidelines: Management of alcohol-related liver disease

M Thursz, A Gual, C Lackner, P Mathurin, C Moreno… - Journal of …, 2018 - Elsevier
The harmful use of alcohol has been estimated to cause approximately 3.3 million deaths
every year, corresponding to nearly 6% of all deaths globally. Therefore, the effective …

Liver diseases: A major, neglected global public health problem requiring urgent actions and large‐scale screening

P Marcellin, BK Kutala - Liver International, 2018 - Wiley Online Library
CLD s represent an important, and certainly underestimated, global public health problem.
CLD s are highly prevalent and silent, related to different, sometimes associated causes …

The relationship between different dimensions of alcohol use and the burden of disease—an update

J Rehm, GE Gmel Sr, G Gmel, OSM Hasan, S Imtiaz… - …, 2017 - Wiley Online Library
Background and aims Alcohol use is a major contributor to injuries, mortality and the burden
of disease. This review updates knowledge on risk relations between dimensions of alcohol …

[HTML][HTML] Alcoholic liver disease: pathogenesis and current management

NA Osna, TM Donohue Jr… - Alcohol research: current …, 2017 - ncbi.nlm.nih.gov
Excessive alcohol consumption is a global healthcare problem. The liver sustains the
greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol …

Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting

MA Avila, JF Dufour, AL Gerbes, F Zoulim, R Bataller… - Gut, 2020 - gut.bmj.com
Alcohol-related liver disease (ALD), which includes a range of disorders of different severity
and is one of the most prevalent types of liver disease worldwide, has recently regained …

Alcoholic liver disease: mechanisms of injury and targeted treatment

A Louvet, P Mathurin - Nature reviews Gastroenterology & hepatology, 2015 - nature.com
Alcoholic liver disease (ALD) is a complex process that includes a wide spectrum of hepatic
lesions, from steatosis to cirrhosis. Cell injury, inflammation, oxidative stress, regeneration …

Prednisolone or pentoxifylline for alcoholic hepatitis

MR Thursz, P Richardson, M Allison… - … England Journal of …, 2015 - Mass Medical Soc
Background Alcoholic hepatitis is a clinical syndrome characterized by jaundice and liver
impairment that occurs in patients with a history of heavy and prolonged alcohol use. The …

Fibrosis and alcohol-related liver disease

C Lackner, D Tiniakos - Journal of hepatology, 2019 - Elsevier
Histological fibrosis stage is one of the most important prognostic factors in compensated
and decompensated alcohol-related liver disease (ALD). Morphological assessment of …