Mitochondrial dysfunction and oxidative stress in Alzheimer's disease, and Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis-an updated …

T Alqahtani, SL Deore, AA Kide, BA Shende, R Sharma… - Mitochondrion, 2023 - Elsevier
Misfolded proteins in the central nervous system can induce oxidative damage, which can
contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients …

Chitosan nanoparticles-based cancer drug delivery: application and challenges

B Sachdeva, P Sachdeva, A Negi, S Ghosh, S Han… - Marine drugs, 2023 - mdpi.com
Chitin is the second most abundant biopolymer consisting of N-acetylglucosamine units and
is primarily derived from the shells of marine crustaceans and the cell walls of organisms …

Machine learning in Alzheimer's disease drug discovery and target identification

C Geng, ZB Wang, Y Tang - Ageing Research Reviews, 2023 - Elsevier
Alzheimer's disease (AD) stands as a formidable neurodegenerative ailment that poses a
substantial threat to the elderly population, with no known curative or disease-slowing drugs …

Unveiling Nature's potential: promising natural compounds in Parkinson's disease management

CK Bhusal, DE Uti, D Mukherjee, T Alqahtani… - Parkinsonism & Related …, 2023 - Elsevier
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the
progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta …

The role of natural and semi-synthetic compounds in ovarian cancer: Updates on mechanisms of action, current trends and perspectives

MR Islam, MM Rahman, PS Dhar, FT Nowrin… - Molecules, 2023 - mdpi.com
Ovarian cancer represents a major health concern for the female population: there is no
obvious cause, it is frequently misdiagnosed, and it is characterized by a poor prognosis …

Ketamine as a therapeutic agent in major depressive disorder and posttraumatic stress disorder: Potential medicinal and deleterious effects

B Sachdeva, P Sachdeva, S Ghosh, F Ahmad… - Ibrain, 2023 - Wiley Online Library
Major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are the most
common causes of emotional distress that impair an individual's quality of life. MDD is a …

Exploring the efficacy of 1-amino-cyclopropane-1-carboxylic acid (ACCA) as a natural compound in strengthening maize resistance against biotic and abiotic stressors …

S Debnath, AM Elgorban, AH Bahkali… - Frontiers in …, 2023 - frontiersin.org
Objective This study aims to understand plant-bacteria interactions that enhance plant
resistance to environmental stressors, with a focus on maize (Zea mays L.) and its …

In silico and in vitro study of bioactive compounds of Nigella sativa for targeting neuropilins in breast cancer

I Zafar, A Safder, H Imran Afridi, S Riaz… - Frontiers in …, 2023 - frontiersin.org
Introduction: Breast cancer poses a significant global challenge, prompting researchers to
explore novel approaches for potential treatments. Material and Methods: For in vitro study …

Exploring the potency of curcumin and phyto-compounds as inhibitors of tomato yellow leaf curl virus-sardinia's DNA-binding domain: a computational approach

AM Elgorban, S Debnath, AH Bahkali… - … and Molecular Plant …, 2023 - Elsevier
Background With the current rise of Tomato yellow leaf curl virus-Sardinia (TYLCV-Sar), a
pathogen causing significant yield losses, conventional pesticides have proven inadequate …

Inhibition of tomato spotted wilt virus nucleocapsid protein using phytochemical lupenone as spraying agent: A cutting-edge computational approach

AM Elgorban, S Debnath, AH Bahkali… - … and Molecular Plant …, 2023 - Elsevier
About & background Tomato spotted wilt virus (TSWV) is one of the most harmful diseases
affecting the growing and making of tomatoes (Solanum lycopersicum) worldwide. With so …