Gene regulatory networks drive the specific transcriptional programmes responsible for the
diversification of cell types during the development of multicellular organisms. Although our …

PARP1, an established anti-cancer target that regulates many cellular pathways, including
DNA repair signaling, has been intensely studied for decades as a poly (ADP-ribosyl) …

The tumor-suppressor breast cancer 1 (BRCA1) in complex with BRCA1-associated really
interesting new gene (RING) domain 1 (BARD1) is a RING-type ubiquitin E3 ligase that …

The spatiotemporal organization of chromatin is regulated at different levels in the nucleus.
Epigenetic modifications such as DNA methylation and histone modifications are involved in …

In eukaryotes, the posttranslational modifier ubiquitin is used to regulate the amounts,
interactions, or activities of proteins in diverse pathways and signaling networks. Its effects …

The recruitment of 53BP1 to chromatin, mediated by its recognition of histone H4
dimethylated at lysine 20 (H4K20me2), is important for DNA double-strand break repair …

Simple Summary Bombyx mori is an important economic insect and a model organism of
Lepidoptera. Its hemolymph contains rich nutrient storage proteins, which participate in …

The attachment of mono-ubiquitin to histones as a post-translational modification plays
important roles in regulating chromatin structure and function. Like other epigenetic …

Background: Radiotherapy (RT) is the primary treatment for diffuse midline glioma (DMG), a
lethal pediatric malignancy defined by histone H3 lysine 27-to-methionine (H3K27M) …

Protein ubiquitylation is an important posttranslational modification that governs most
cellular processes. Signaling functions of ubiquitylation are very diverse and involve …