Advancing age promotes cardiovascular disease (CVD), the leading cause of death in the
United States and many developed nations. Two major age-related arterial phenotypes …

Endothelial cells control vascular tone by releasing nitric oxide (NO) produced by
endothelial NO synthase. The activity of endothelial NO synthase is modulated by the …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …

Background: The catalytic subunit of telomerase, telomerase reverse transcriptase (TERT),
has protective functions in the cardiovascular system. TERT is not only present in the …

Shortened telomeres have been linked to numerous chronic diseases, most importantly
coronary artery disease, but the underlying mechanisms remain ill defined. Loss-of-function …

Until recently, it has been generally held that stable angina pectoris (SAP) primarily reflects
the presence of epicardial coronary artery stenoses due to atheromatous plaque (s), while …

Telomeres are specialised structures at the end of linear chromosomes. They consist of
tandem repeats of the hexanucleotide sequence TTAGGG, as well as a protein complex …

Coronary artery disease (CAD) is a leading cause of death worldwide and frequently
associated with mitochondrial dysfunction. Detailed understanding of abnormalities in …