The progressive increase in lifespan over the past century carries with it some adversity
related to the accompanying burden of debilitating diseases prevalent in the older …

The convergence of tissue engineering and patient-specific stem cell biology has enabled
the engineering of in vitro tissue models that allow the study of patient-tailored treatment …

This study developed an approach to quantify frailty with a frailty index (FI) and investigated
whether age-related changes in contractions, calcium transients, and ventricular myocyte …

G protein-coupled receptors (GPCRs), comprising the largest superfamily of cell surface
receptors, serve as fundamental modulators of cardiac health and disease owing to their key …

Patients with heart failure (HF) have a high prevalence of depression associated with a
worse prognosis, particularly in older women. The present study evaluated whether sex and …

Myocardial remodeling after myocardial infarction (MI) is associated with increased levels of
the matrix metalloproteinases (MMPs). Levels of two MMP species, MMP-2 and MMP-9, are …

Background Whether cigarette smoking affects the heart post-myocardial infarction (MI) in a
sex-dependent way remains controversial. Using a mouse model, we investigated cardiac …

The higher cardiovascular risk in men and post-menopausal women implies a protective
action of estrogen. A large number of experimental studies have provided strong support to …

BACKGROUND: Recent studies have demonstrated that aging is associated with reduced
tolerance to ischemia and that the aged (not senescent) female heart has greater …

The ischemic etiology of heart failure is an independent prognostic factor associated with
worse long-term outcome. Recent evidence indicates a role for genetic susceptibility to …