Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …

DNA damage is a constant source of stress challenging genomic integrity. To ensure faithful
duplication of our genomes, mechanisms have evolved to deal with damage encountered …

In human cells, the DNA replication factor proliferating cell nuclear antigen (PCNA) can be
conjugated to either the small ubiquitinlike modifier SUMO1 or SUMO2, but only SUMO2 …

The MUS81-EME1 endonuclease cleaves late replication intermediates at common fragile
sites (CFSs) during early mitosis to trigger DNA-repair synthesis that ensures faithful …

Accurate transmission of the genetic information requires complete duplication of the
chromosomal DNA each cell division cycle. However, the idea that replication forks would …

The complete and faithful duplication of the genome is an essential prerequisite for
proliferating cells to maintain genome integrity. This objective is greatly challenged by DNA …

DNA damage tolerance pathways, which include translesion DNA synthesis (TLS) and
template switching, are crucial for prevention of DNA replication arrest and maintenance of …

RAD51 recombinase plays a central role in homologous recombination (HR) by forming a
nucleoprotein filament on single-stranded DNA (ssDNA) to catalyze homology search and …

Abstract The Saccharomyces cerevisiae Srs2 DNA helicase has important roles in DNA
replication, recombination and repair. In replication, Srs2 aids in repair of gaps by repair …

Homologous recombination is essential for DNA repair, replication and the exchange of
genetic material between parental chromosomes during meiosis. The stages of …