In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …

Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …

Chromatin is important for the regulation of transcription and other functions, yet the diversity
of chromatin composition and the distribution along chromosomes are still poorly …

The three-dimensional organization of chromosomes within the nucleus and its dynamics
during differentiation are largely unknown. To visualize this process in molecular detail, we …

The factors that sequester transcriptionally repressed heterochromatin at the nuclear
periphery are currently unknown. In a genome-wide RNAi screen, we found that depletion of …

The genome is packaged and organized nonrandomly within the 3D space of the nucleus to
promote efficient gene expression and to faithfully maintain silencing of heterochromatin …

The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …

Nuclear pore complexes (NPCs) mediate transport across the nuclear envelope. In yeast,
they also interact with active genes, attracting or retaining them at the nuclear periphery. In …

Non-random positioning of chromosomal domains relative to each other and to nuclear
landmarks is a common feature of eukaryotic genomes. In particular, the distribution of DNA …