Precision medicine seeks to maximize the quality of health care by individualizing the health-
care process to the uniquely evolving health status of each patient. This endeavor spans a …

Abstract After the 2011 Institute of Medicine report on chronic pain, the Interagency Pain
Research Coordinating Committee (IPRCC) was created to enhance research efforts among …

Dynamic Treatment Regimes: Statistical Methods for Precision Medicine provides a
comprehensive introduction to statistical methodology for the evaluation and discovery of …

Many questions regarding the clinical management of people experiencing pain and related
health policy decision-making may best be answered by pragmatic controlled trials. To …

It is estimated that behaviors such as poor diet, alcohol consumption, tobacco use,
sedentary behavior, and excessive ultraviolet exposure account for nearly one-half of all …

Purpose Fatigue and pain are common among women with breast cancer, and often related
to depressive symptoms. Social support may influence levels of fatigue, pain interference …

Background Diet and exercise may be associated with quality of life and survival in men with
prostate cancer. Objective This study aimed to determine the feasibility and acceptability of a …

Sequential multiple assignments randomized trials (SMARTs) are a type of experimental
design where patients may be randomised multiple times according to pre-specified …

Behavioral pain management interventions are efficacious for reducing pain in patients with
cancer. However, optimal dosing of behavioral pain interventions for pain reduction is …

Abstract Objective Sequential Multiple Assignment Randomized Trial (SMART) designs
allow multiple randomizations of participants; this allows assessment of stage-specific …