Proteus mirabilis is a Gram negative bacterium that is a frequent cause of catheter-
associated urinary tract infections (CAUTIs). Its ability to cause such infections is mostly …

Urease is a nickel-dependent metalloenzyme found in plants, some bacteria, and fungi.
Bacterial enzyme is of special importance since it has been demonstrated as a potent …

Fluoroquinolones remain one of the most important kind of antibacterial agents used
nowadays. The emergence of more virulent and resistant strains of bacteria by the …

Screening of 25 analogs of Ebselen, diversified at the N-aromatic residue, led to the
identification of the most potent inhibitors of Sporosarcina pasteurii urease reported to date …

One of the main reasons for the bacterial resistance to antibiotics is caused by biofilm
formation of microbial pathogens during bacterial infections. Salmonella enterica and Vibrio …

New hydroxamic acid, hydrazide and amide derivatives of ciprofloxacin in addition to their
analogues of levofloxacin were prepared and identified by different spectroscopic …

Involvement of urease in various pathological conditions specifically in gastric and peptic
ulcers make it an important therapeutic target. In the present study urease inhibition was …

A new series of 6-substituted quinolin-2-one thiosemicarbazides 6a–j has been synthesized.
The structure of the target compounds was proved by different spectroscopic and elemental …

Abstract New N-4-piperazinyl ciprofloxacin-triazole hybrids 6a-o were prepared and
characterized. The in vitro antimycobacterial activity revealed that compound 6a …

Background Proteus mirabilis is a significant nosocomial pathogen that is frequently
associated with a wide range of infections, necessitating heightened attention to mitigate …