[HTML][HTML] Diabetes mellitus and diabetic foot ulcer: Etiology, biochemical and molecular based treatment strategies via gene and nanotherapy

AVA Mariadoss, AS Sivakumar, CH Lee… - Biomedicine & …, 2022 - Elsevier
Diabetes mellitus (DM) is a collection of metabolic and pathophysiological disorders
manifested with high glucose levels in the blood due to the inability of β-pancreatic cells to …

Chitosan-based therapeutic systems and their potentials in treatment of oral diseases

H Gao, N Wu, N Wang, J Li, J Sun, Q Peng - International Journal of …, 2022 - Elsevier
The increasing morbidity of oral diseases, such as dental caries, periodontitis and oral
cancer, has greatly compromised the life quality of humans. With the rapid development of …

Folic acid functionalized starch encapsulated green synthesized copper oxide nanoparticles for targeted drug delivery in breast cancer therapy

AVA Mariadoss, K Saravanakumar… - International Journal of …, 2020 - Elsevier
This work aimed to synthesis copper oxide nanoparticles (CuONPs) using the Helianthus
tuberosus (Ht) extracts then encapsulated with starch (ST) followed by conjugated with folic …

Sweet tea (Lithocarpus polystachyus rehd.) as a new natural source of bioactive dihydrochalcones with multiple health benefits

A Shang, HY Liu, M Luo, Y Xia, X Yang… - Critical Reviews in …, 2022 - Taylor & Francis
Abstract Sweet tea (Lithocarpus polystachyus Rehd.) has been consumed as herbal tea to
prevent and manage diabetes for a long time. Recent studies indicate that sweet tea is rich …

[HTML][HTML] Chitosan-tripolyphosphate nanoparticles designed to encapsulate polyphenolic compounds for biomedical and pharmaceutical applications− A review

MC Di Santo, CL D'Antoni, APD Rubio, A Alaimo… - Biomedicine & …, 2021 - Elsevier
Plant-based polyphenols are natural compounds, present in fruits and vegetables. During
recent years, polyphenols have gained special attention due to their nutraceutical and …

Bioaccessibility and intracellular antioxidant activity of phloretin embodied by gliadin/sodium carboxymethyl cellulose nanoparticles

JR He, JJ Zhu, SW Yin, XQ Yang - Food Hydrocolloids, 2022 - Elsevier
In this work, gliadin/sodium carboxymethyl cellulose nanoparticles (G/CMC) were prepared
to encapsulate bioactive phloretin (Phl) for improving the stability and bioaccessibility by …

Therapeutic potential and pharmaceutical development of a multitargeted flavonoid phloretin

KT Nakhate, H Badwaik, R Choudhary, K Sakure… - Nutrients, 2022 - mdpi.com
Phloretin is a flavonoid of the dihydrogen chalcone class, present abundantly in apples and
strawberries. The beneficial effects of phloretin are mainly associated with its potent …

Enhanced anti-cancer activity of chitosan loaded Morinda citrifolia essential oil against A549 human lung cancer cells

G Rajivgandhi, K Saravanan, G Ramachandran… - International journal of …, 2020 - Elsevier
In the present study, the chemical composition of Morinda citrifolia essential oils was
determined by gas chromatography–mass spectrometry and was found to contain several …

Nanoparticle effects on stress response pathways and nanoparticle–protein interactions

SJ Cameron, J Sheng, F Hosseinian… - International journal of …, 2022 - mdpi.com
Nanoparticles (NPs) are increasingly used in a wide variety of applications and products;
however, NPs may affect stress response pathways and interact with proteins in biological …

The molecular pharmacology of phloretin: anti-inflammatory mechanisms of action

S Habtemariam - Biomedicines, 2023 - mdpi.com
The isolation of phlorizin from the bark of an apple tree in 1835 led to a flurry of research on
its inhibitory effect on glucose transporters in the intestine and kidney. Using phlorizin as a …