Genetic analyses have suggested that complex networks of interacting developmental
regulators expressed in overlapping temporal and spatial patterns ultimately lead to …

POU domain factors are transcriptional regulators characterized by a highly conserved DNA-
binding domain referred to as the POU domain. The structure of the POU domain has been …

We have analysed various adult organs and different developmental stages of mouse
embryos for the presence of octamer‐binding proteins. A variety of new octamer‐binding …

Oct‐4 is a maternally expressed octamer‐binding protein encoded by the murine Oct‐4
gene. It is present in unfertilized oocytes, but also in the inner cell mass and in primordial …

The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with I
kappa B-alpha and other proteins that bind to members of the Rel protein family. Here, we …

We describe the cDNA encoding the SV40 transcriptional enhancer factor 1 (TEF-1) and
show that its translation initiates exclusively at an AUU codon in vivo. Cloned TEF-1, which …

The muE3 motif within the immunoglobulin heavy-chain enhancer is required for full
enhancer activity and is known to bind one, or perhaps a family, of related ubiquitous …

The ubiquitous Ott-1 and lymphoid Ott-2 POU homeodomain transcription factors bind to the
same DNA sequence but differ in their activation potential. Ott-2 is a positive, negative, or …

The human immunodeficiency virus (HIV-1)-encoded trans-activator (tat) increases HIV
gene expression and replication. Previously, we demonstrated that tat facilitates elongation …

The herpes simplex virus transactivator VP16 par-ticipates in the formation of a multiprotein-
DNA complex with the ubiquitous octamer-motif-binding factor Oct-1. Complex formation is …