Protein phosphatases are the essential opposite to protein kinases; together, these enzymes
regulate all protein phosphorylation and most cellular processes. To better understand the …

The two members of the UBASH3/STS/TULA protein family have been shown to critically
regulate key biological functions, including immunity and hemostasis, in mammalian …

The protein tyrosine kinase Syk plays a critical role in FcεRI signaling in mast cells. Binding
of Syk to phosphorylated immunoreceptor tyrosine‐based activation motifs (p‐ITAM) of the …

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies resistant to
current chemotherapies or radiotherapies, which makes it urgent to identify new therapeutic …

We determined the substrate specificities of the protein tyrosine phosphatases (PTPs)
PTP1B, RPTPα, SHP-1, and SHP-2 by on-bead screening of combinatorial peptide libraries …

Although over 40 type 1 diabetes (T1D) risk loci have been mapped in humans, the
causative genes and variants for T1D are largely unknown. Here, we investigated a …

Two major types of leukemogenic BCR-ABL fusion proteins are p190 BCR-ABL and p210
BCR-ABL. Although the two fusion proteins are closely related, they can lead to different …

The TCR–CD3 complex is a multicomponent membrane receptor, the expression of which is
tightly regulated in thymocytes, as well as in mature T cells both at steady state and upon …

Fc receptor for IgG IIA (FcγRIIA)–mediated platelet activation is essential in heparin-induced
thrombocytopenia (HIT) and other immune-mediated thrombocytopenia and thrombosis …

T cell activity is controlled in large part by the T cell receptor (TCR). The TCR detects the
presence of foreign pathogens and activates the T cell-mediated immune reaction …