Safety of the fungal workhorses of industrial biotechnology: update on the mycotoxin and secondary metabolite potential of Aspergillus niger, Aspergillus oryzae, and …

JC Frisvad, LLH Møller, TO Larsen, R Kumar… - Applied Microbiology …, 2018 - Springer
This review presents an update on the current knowledge of the secondary metabolite
potential of the major fungal species used in industrial biotechnology, ie, Aspergillus niger …

Oxidative cyclization in natural product biosynthesis

MC Tang, Y Zou, K Watanabe, CT Walsh… - Chemical …, 2017 - ACS Publications
Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Taxonomy of Aspergillus section Flavi and their production of aflatoxins, ochratoxins and other mycotoxins

JC Frisvad, V Hubka, CN Ezekiel, SB Hong… - Studies in …, 2019 - ingentaconnect.com
Aflatoxins and ochratoxins are among the most important mycotoxins of all and producers of
both types of mycotoxins are present in Aspergillus section Flavi, albeit never in the same …

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action

Y Yan, Q Liu, X Zang, S Yuan, U Bat-Erdene, C Nguyen… - Nature, 2018 - nature.com
Bioactive natural products have evolved to inhibit specific cellular targets and have served
as lead molecules for health and agricultural applications for the past century,–. The post …

Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining

CY Chiang, M Ohashi, Y Tang - Natural product reports, 2023 - pubs.rsc.org
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

Class II terpene cyclases: structures, mechanisms, and engineering

X Pan, JD Rudolf, LB Dong - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to July 2023 Terpene cyclases (TCs) catalyze some of the most complicated
reactions in nature and are responsible for creating the skeletons of more than 95 000 …

[HTML][HTML] Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity

X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Terpene synthases in disguise: enzymology, structure, and opportunities of non-canonical terpene synthases

JD Rudolf, CY Chang - Natural product reports, 2020 - pubs.rsc.org
Covering: up to July 2019 Terpene synthases (TSs) are responsible for generating much of
the structural diversity found in the superfamily of terpenoid natural products. These elegant …

Detecting and prioritizing biosynthetic gene clusters for bioactive compounds in bacteria and fungi

PN Tran, MR Yen, CY Chiang, HC Lin… - Applied microbiology and …, 2019 - Springer
Secondary metabolites (SM) produced by fungi and bacteria have long been of exceptional
interest owing to their unique biomedical ramifications. The traditional discovery of new …

Strategies for engineering natural product biosynthesis in fungi

E Skellam - Trends in Biotechnology, 2019 - cell.com
Fungi are a prolific source of bioactive compounds, some of which have been developed as
essential medicines and life-enhancing drugs. Genome sequencing has revealed that fungi …