The human endometrium is a highly dynamic tissue that is cyclically shed, repaired,
regenerated and remodelled, primarily under the orchestration of oestrogen and …

Nanomedicines have significant potential for cancer treatment. Although the majority of
nanomedicines currently tested in clinical trials utilize simple, biocompatible liposome …

Rapid innovations in nanomedicine have increased the likelihood that engineered
nanomaterials will eventually come in contact with humans and the environment. The advent …

The surface of a cell represents a collection of macromolecules, which provides the cell with
a unique cellular landscape specific to the type and state of the cell. Ligands that …

The relative impermeability of the blood-brain barrier (BBB) results from tight junctions and
efflux transport systems limits drug delivery to the central nervous system (CNS), and thus …

The discovery of hybridoma technology, described by Kohler and Milstein in 1975, and the
resulting ability to generate monoclonal antibodies (mAbs) initiated a new era in antibody …

Non-viral vectors continue to be an attractive alternative to viral vectors due to their safety,
versatility and ease of preparation and scale-up. Over the past few years, investigators have …

The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-
based therapeutics, such as drugs encapsulated within polymeric particles. Here, we …

Transfer across the blood‐brain barrier (BBB) remains a significant hurdle for the
development of biopharmaceuticals with therapeutic effects within the central nervous …

Recognition of molecular diversity of cell surface proteomes in disease is essential for the
development of targeted therapies. Progress in targeted therapeutics requires establishing …