Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have
become methods of choice to characterize the human metabolome and MS-based …

Background Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult
disability. There is no cure for OA and there is no effective treatment to stop its progression …

The pathological changes in osteoarthritis—a degenerative joint disease prevalent among
older people—start at the molecular scale and spread to the higher levels of the architecture …

Metabolomics enables the profiling of large numbers of small molecules in cells, tissues and
biological fluids. These molecules, which include amino acids, carbohydrates, lipids …

Osteoarthritis (OA) is a progressive disorder characterized by destruction of articular
cartilage and subchondral bone, and by synovial changes. The diagnosis of OA is generally …

Osteoarthritis affects over 250 million individuals worldwide. Currently, there are no options
for early diagnosis of osteoarthritis, demonstrating the need for biomarker discovery. To find …

Objective There is a pressing need to develop reliable molecular biomarkers in
osteoarthritis. The aim of the study was to identify novel serum biomarkers for osteoarthritis …

Objective The objective of this exploratory study was to determine if perturbations in gut
microbial composition and the gut metabolome could be linked to individuals with obesity …

Objective The aim of this systematic review was to analyze the evidence about the efficacy of
the several synovial fluid (SF) biomarkers proposed for knee osteoarthritis (OA), categorizing …

Objective To evaluate diurnal variation of biomarkers in subjects with osteoarthritis (OA) of
the knee. Methods Twenty subjects with radiographic knee OA were admitted to the General …