Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …
organ development, epithelial homeostasis, tissue regeneration, wound healing and …
YAP/TAZ at the roots of cancer
F Zanconato, M Cordenonsi, S Piccolo - Cancer cell, 2016 - cell.com
YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …
YAP/TAZ: drivers of tumor growth, metastasis, and resistance to therapy
BJ Thompson - Bioessays, 2020 - Wiley Online Library
The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …
activated during the growth and progression of many solid tumors, including lung, colorectal …
KRAS and YAP1 converge to regulate EMT and tumor survival
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of
the mutant allele for survival, but the molecular basis of this oncogene dependency remains …
the mutant allele for survival, but the molecular basis of this oncogene dependency remains …
Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
Activating mutations in KRAS are among the most frequent events in diverse human
carcinomas and are particularly prominent in human pancreatic ductal adenocarcinoma …
carcinomas and are particularly prominent in human pancreatic ductal adenocarcinoma …
The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain
JM Lamar, P Stern, H Liu… - Proceedings of the …, 2012 - National Acad Sciences
The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ
size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue …
size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue …
[HTML][HTML] YAP1 and its fusion proteins in cancer initiation, progression and therapeutic resistance
YAP1 is a transcriptional co-activator whose activity is controlled by the Hippo signaling
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
pathway. In addition to important functions in normal tissue homeostasis and regeneration …
Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates
and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a …
and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a …
The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway
The Hippo signaling pathway was initially defined by genetic studies in Drosophila to
regulate tissue growth and organ size [1, 2]. This pathway is highly conserved in mammals …
regulate tissue growth and organ size [1, 2]. This pathway is highly conserved in mammals …
The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression
The Hippo signaling pathway controls organ size and tumorigenesis through a kinase
cascade that inactivates Yes‐associated protein (YAP). Here, we show that YAP plays a …
cascade that inactivates Yes‐associated protein (YAP). Here, we show that YAP plays a …