Pseudomonas aeruginosa is an opportunistic pathogen affecting immunocompromised
patients. It is known as the leading cause of morbidity and mortality in cystic fibrosis (CF) …

Biofilm formation of microorganisms causes persistent tissue and foreign body infections
resistant to treatment with antimicrobial agents. Up to 80% of human bacterial infections are …

Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Bacteria can be adapted to adverse and detrimental conditions that induce general and
specific responses to DNA damage as well as acid, heat, cold, starvation, oxidative …

Antibiotic resistance can be acquired by mutation or horizontal transfer of a resistance gene,
and generally an acquired mechanism results in a predictable increase in phenotypic …

It is generally assumed that antibiotics and resistance determinants are the task forces of a
biological warfare in which each resistance determinant counteracts the activity of a specific …

Bacteria encounter a myriad of potentially growth-compromising conditions in nature and in
hosts of pathogenic bacteria. These 'stresses' typically elicit protective and/or adaptive …

Colistin resistance in Acinetobacter baumannii is of great concern and is a threat to human
health. In this study, we investigate the mechanisms of colistin resistance in four isogenic …

As drug-resistant pathogens continue to emerge, combination therapy will increasingly be
relied upon to treat infections and to help combat further development of multidrug …

Single cell microorganisms including pathogens relentlessly face myriads of
physicochemical stresses in their living environment. In order to survive and multiply under …