T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …

Naturally occurring CD4+ regulatory T cells (Tregs), which specifically express the
transcription factor FoxP3 in the nucleus and CD25 and CTLA-4 on the cell surface, are a …

Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …

More than 90% of cases of hepatocellular carcinoma (HCC) occurs in patients with cirrhosis,
of which hepatitis B virus and hepatitis C virus are the leading causes, while the tumor less …

Inflammatory bowel disease (IBD) is an umbrella term for the chronic immune-mediated
idiopathic inflammation of the gastrointestinal tract, manifesting as Crohn's disease (CD) or …

Recent years have seen significant efforts in understanding and modulating the immune
response in cancer. In this context, immunosuppressive cells, including regulatory T cells …

CD4+ T cells differentiate and acquire distinct functions to combat specific pathogens but
can also adapt their functions in response to changing circumstances. Although this …

FOXP3+ Tregs are central for the maintenance of self-tolerance and can be defective in
autoimmunity. In multiple sclerosis and type-1 diabetes, dysfunctional self-tolerance is …

Regulatory T (TReg) cells are crucial for the prevention of fatal autoimmunity in mice and
humans. Forkhead box P3 (FOXP3)+ TReg cells are produced in the thymus and are also …

Regulatory T cells (Tregs) are central to the maintenance of self-tolerance and tissue
homeostasis. Markers commonly used to define human Tregs in the research setting include …