[HTML][HTML] The biology of CRISPR-Cas: backward and forward
F Hille, H Richter, SP Wong, M Bratovič, S Ressel… - Cell, 2018 - cell.com
In bacteria and archaea, clustered regularly interspaced short palindromic repeats
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
(CRISPR) and CRISPR-associated (Cas) proteins constitute an adaptive immune system …
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
BACKGROUND Prokaryotes have evolved multiple systems to combat invaders such as
viruses and plasmids. Examples of such defense systems include receptor masking …
viruses and plasmids. Examples of such defense systems include receptor masking …
CRISPR-Cas: biology, mechanisms and relevance
F Hille, E Charpentier - … of the royal society B: biological …, 2016 - royalsocietypublishing.org
Prokaryotes have evolved several defence mechanisms to protect themselves from viral
predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their …
predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their …
Molecular mechanisms of CRISPR-Cas immunity in bacteria
PM Nussenzweig, LA Marraffini - Annual review of genetics, 2020 - annualreviews.org
Prokaryotes have developed numerous defense strategies to combat the constant threat
posed by the diverse genetic parasites that endanger them. Clustered regularly interspaced …
posed by the diverse genetic parasites that endanger them. Clustered regularly interspaced …
Anti-CRISPR: discovery, mechanism and function
CRISPR–Cas adaptive immune systems are widespread among bacteria and archaea.
Recent studies have shown that these systems have minimal long-term evolutionary effects …
Recent studies have shown that these systems have minimal long-term evolutionary effects …
A century of the phage: past, present and future
GPC Salmond, PC Fineran - Nature Reviews Microbiology, 2015 - nature.com
Viruses that infect bacteria (bacteriophages; also known as phages) were discovered 100
years ago. Since then, phage research has transformed fundamental and translational …
years ago. Since then, phage research has transformed fundamental and translational …
CRISPR-Cas: adapting to change
BACKGROUND The arms race between prokaryotes and their perpetually evolving
predators has fueled the evolution of a defense arsenal. The so-called CRISPR-Cas …
predators has fueled the evolution of a defense arsenal. The so-called CRISPR-Cas …
[HTML][HTML] The CRISPR-Cas immune system: biology, mechanisms and applications
Viruses are a common threat to cellular life, not the least to bacteria and archaea who
constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus …
constitute the majority of life on Earth. Consequently, a variety of mechanisms to resist virus …
Molecular mechanisms of CRISPR–Cas spacer acquisition
J McGinn, LA Marraffini - Nature Reviews Microbiology, 2019 - nature.com
Many bacteria and archaea have the unique ability to heritably alter their genomes by
incorporating small fragments of foreign DNA, called spacers, into CRISPR loci. Once …
incorporating small fragments of foreign DNA, called spacers, into CRISPR loci. Once …
[HTML][HTML] A highly abundant bacteriophage discovered in the unknown sequences of human faecal metagenomes
Metagenomics, or sequencing of the genetic material from a complete microbial community,
is a promising tool to discover novel microbes and viruses. Viral metagenomes typically …
is a promising tool to discover novel microbes and viruses. Viral metagenomes typically …