The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key
roles in the development of many organs and tissues, and are deregulated in birth defects …

Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased
risk of developing several malignancies. The biological and pathogenic importance of Hh …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease caused by the
malignant transformation of immature progenitors primed towards T-cell development …

Abstract Bardet–Biedl Syndrome (BBS) is a pleiotropic genetic disease caused by the
dysfunction of primary cilia. The immune system of patients with ciliopathies has not been …

GLI transcription factors have important roles in intracellular signaling cascade, acting as the
main mediators of the HH-GLI signaling pathway. This is one of the major developmental …

The Hedgehog (HH) signaling network is one of the main regulators of invertebrate and
vertebrate embryonic development. Along with other networks, such as NOTCH and WNT …

Generation of a self-tolerant but antigen-responsive T cell repertoire occurs in the thymus.
Although glucocorticoids are usually considered immunosuppressive, there is also evidence …

Epithelial barrier tissues such as the skin and airway form an essential interface between the
mammalian host and its external environment. These physical barriers are crucial to prevent …

With regard to Hedgehog signaling in mammalian development, the majority of research has
focused on Gli2 and Gli3 rather than Gli1. This is because Gli1−/− mice do not show any …