[HTML][HTML] Macrophage rewiring by nutrient associated PI3K dependent pathways
O Sharif, JS Brunner, A Vogel… - Frontiers in …, 2019 - frontiersin.org
Class 1 Phosphoinositide-3-Kinases (PI3Ks) have been widely studied and mediate
essential roles in cellular proliferation, chemotaxis, insulin sensitivity, and immunity. Here …
essential roles in cellular proliferation, chemotaxis, insulin sensitivity, and immunity. Here …
Fungal antitumor protein D1 is internalized via endocytosis and inhibits non-small cell lung cancer proliferation through MAPK signaling pathway
MH Zhang, JH Wong, F Liu, TB Ng, ZK Liu - International Journal of …, 2023 - Elsevier
Lung cancer has the highest mortality among cancer-related deaths worldwide. Among lung
cancers, non-small cell lung cancer (NSCLC) is the most common histological type. In the …
cancers, non-small cell lung cancer (NSCLC) is the most common histological type. In the …
MicroRNA-134 actives lipoprotein lipase-mediated lipid accumulation and inflammatory response by targeting angiopoietin-like 4 in THP-1 macrophages
G Lan, W Xie, L Li, M Zhang, D Liu, YL Tan… - Biochemical and …, 2016 - Elsevier
Abstract Angiopoietin-like 4 (Angptl4), a secreted protein, is an important regulator to
irreversibly inhibit lipoprotein lipase (LPL) activity. Macrophage LPL contributes to foam cell …
irreversibly inhibit lipoprotein lipase (LPL) activity. Macrophage LPL contributes to foam cell …
Apelin-13 inhibits lipoprotein lipase expression via the APJ/PKCα/miR-361-5p signaling pathway in THP-1 macrophage-derived foam cells
X Zhang, Q Ye, D Gong, Y Lv, H Cheng… - Acta biochimica et …, 2017 - academic.oup.com
Atherosclerotic lesions are characterized by the accumulation of abundant lipids and chronic
inflammation. Previous researches have indicated that macrophage-derived lipoprotein …
inflammation. Previous researches have indicated that macrophage-derived lipoprotein …
[HTML][HTML] Overexpression of toll-like receptor 4 contributes to phagocytosis of Salmonella enterica Serovar Typhimurium via phosphoinositide 3-kinase signaling in …
S Wang, S Deng, Y Cao, R Zhang, Z Wang… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Phagocytosis of bacteria by monocytes/macrophages can trigger the
immune response and the clearance of bacteria. This innate immune response involves Toll …
immune response and the clearance of bacteria. This innate immune response involves Toll …
[HTML][HTML] Data on gene and protein expression changes induced by apabetalone (RVX-208) in ex vivo treated human whole blood and primary hepatocytes
S Wasiak, D Gilham, LM Tsujikawa, C Halliday… - Data in brief, 2016 - Elsevier
Abstract Apabetalone (RVX-208) inhibits the interaction between epigenetic regulators
known as bromodomain and extraterminal (BET) proteins and acetyl-lysine marks on …
known as bromodomain and extraterminal (BET) proteins and acetyl-lysine marks on …
Proteomic analysis reveals the mechanisms of the astaxanthin suppressed foam cell formation
A Liu, R Li, F Zaaboul, M He, X Li, J Shi, Y Liu, YJ Xu - Life Sciences, 2023 - Elsevier
Aims Lipid metabolism in macrophages plays a key role in atherosclerosis development.
Excessive low-density lipoprotein taken by macrophages leads to foam cell formation. In this …
Excessive low-density lipoprotein taken by macrophages leads to foam cell formation. In this …
Role of Kir2. 1 in human monocyte‐derived foam cell maturation
W Zhang, XJ Lei, YF Wang, DQ Wang… - Journal of cellular and …, 2016 - Wiley Online Library
The role of K+ channels in macrophage immunomodulation has been well‐established.
However, it remains unclear whether K+ channels are involved in the lipid uptake of …
However, it remains unclear whether K+ channels are involved in the lipid uptake of …
Monitoring Modified LipoproteinUptake and Macropinocytosis Associated with Macrophage Foam Cell Formation
A Alahmadi, DP Ramji - Atherosclerosis: Methods and Protocols, 2022 - Springer
Macrophage foam cell formation plays a crucial role in the initiation and progression of
atherosclerosis. Macrophages uptake native and modified low density lipoprotein (LDL) …
atherosclerosis. Macrophages uptake native and modified low density lipoprotein (LDL) …
Shikonin inhibits TNF-α-induced growth and invasion of rat aortic vascular smooth muscle cells
X Zhang, W Hu, F Wu, X Yuan… - Canadian Journal of …, 2015 - cdnsciencepub.com
Shikonin is a naphthoquinone compound extracted from the Chinese herb purple gromwell.
Shikonin has broad antibacterial, anti-inflammatory, and antitumor activities. The tumor …
Shikonin has broad antibacterial, anti-inflammatory, and antitumor activities. The tumor …