Ever since Claude Bernards discovery in the mid 19th-century that a lesion in the floor of the
third ventricle in dogs led to altered systemic glucose levels, a role of the CNS in whole-body …

The CCK (1) receptor is a G-protein-coupled receptor activated by the sulfated forms of
cholecystokinin (CCK), a gastrin-like peptide released in the gastrointestinal tract and …

Whether synapses in appetite-regulatory brain regions undergo long-term changes in
strength in response to satiety peptides is poorly understood. Here we show that following …

Pulses are low-glycaemic foods rich in protein (20–25%), resistant starch and fibre that
suppress appetite and glycaemia. The objective of the present study was to elucidate the …

Ghrelin is a 28 amino acid peptide hormone that targets the brain to promote feeding and
adiposity. The ghrelin receptor, the GHSR1a, is expressed within most hypothalamic nuclei …

Laboratory rats, throughout the 24hour day, alternate between behaviorally active and non
active episodes that Kleitman called the basic rest–activity cycle (BRAC). We previously …

Background Feeding rhythm disruption contributes to the development of obesity. The
receptors of glucagon-like peptide-1 (GLP-1) are distributed in the wide regions of the brain …

Introduction: With the increasing prevalence of obesity and its associated comorbidities,
strides to improve treatment strategies have enhanced our understanding of the function of …

The central nervous system relies on a continual supply of glucose, and must be able to
detect glucose levels and regulate peripheral organ functions to ensure that its energy …

Intracranial chemical injection (ICI) methods have been used to identify the locations in the
brain where feeding behavior can be controlled acutely. Scientists conducting ICI studies …