Reactive oxygen species (ROS) and mitochondria play a pivotal role in regulating platelet
functions. Platelet activation determines a drastic change in redox balance and in platelet …

Reactive oxygen species (ROS) are generated within activated platelets and play an
important role in regulating platelet responses to collagen and collagen-mediated thrombus …

Over the two past decades, mutations of the PTPN11 gene, encoding the ubiquitous protein
tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been …

Epithelial–mesenchymal transition (EMT) is recognized as a driving force of cancer cell
metastasis and drug resistance, two leading causes of cancer recurrence and cancer …

This textbook describes the basic principles of induced organ regeneration in skin and
peripheral nerves and extends the original successful paradigm to other organs. A set of …

Aging is associated with an increased incidence of cardiovascular disease and thrombosis.
Platelets play a major role in maintaining hemostasis and in thrombus formation, making …

Abstract Significance: Hydrogen peroxide (H2O2) is produced on stimulation of many cell
surface receptors and serves as an intracellular messenger in the regulation of diverse …

Depression is a major cause of morbidity and low quality of life among patients with
cardiovascular disease (CVD), and it is now considered as an independent risk factor for …

Mast cells are a heterogeneous multifunctional cellular population that promotes connective
tissue homeostasis by slow release of biologically active substances, affecting primarily the …

Background The ingestion of flavonoids has been reported to be associated with reduced
cardiovascular disease risk. Quercitrin is a common flavonoid in nature, and it exhibits …