Challenges and issues with streptozotocin-induced diabetes–a clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics

SN Goyal, NM Reddy, KR Patil, KT Nakhate… - Chemico-biological …, 2016 - Elsevier
Streptozotocin (STZ) has been extensively used over the last three decades to induce
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …

Maximal exercise test is a useful method for physical capacity and oxygen consumption determination in streptozotocin-diabetic rats

B Rodrigues, DM Figueroa, CT Mostarda… - Cardiovascular …, 2007 - Springer
Background The aim of the present study was to investigate the relationship between speed
during maximum exercise test (ET) and oxygen consumption (VO 2) in control and STZ …

Diabetes and cardiovascular autonomic dysfunction: application of animal models

K De Angelis, MC Irigoyen, M Morris - Autonomic Neuroscience, 2009 - Elsevier
When diabetes is associated with cardiovascular autonomic dysfunction, there is a poor
prognosis and increased morbidity and mortality. Information on the mechanisms of diabetes …

Effect of guizhi decoction (桂枝汤) on heart rate variability and regulation of cardiac autonomic nervous imbalance in diabetes mellitus rats

X Li, Y Jiang, P Jiang, J Yang, D Ma, C Yang - Chinese journal of …, 2014 - Springer
Objective To observe abnormalities in heart rate variability (HRV) in diabetic rats and to
explore the effects of treatment with Guizhi Decoction (桂枝汤) on cardiac autonomic …

Combined aerobic and resistance exercise training attenuates cardiac dysfunctions in a model of diabetes and menopause

IC Sanches, M Buzin, FF Conti, DS Dias, CP Santos… - PLoS …, 2018 - journals.plos.org
The study aimed at evaluating the effects of combined aerobic and resistance exercise
training on cardiac morphometry and function, oxidative stress and inflammatory parameters …

Exercise training improves arterial baro-and chemoreflex in control and diabetic rats

AD Harthmann, K De Angelis, LP Costa… - Autonomic …, 2007 - Elsevier
We investigated the effect of exercise training on blood pressure, heart rate, and arterial
baro-and chemoreflex sensitivity in diabetic rats (streptozotocin, 50 mg/kg iv). Male Wistar …

Benefits of exercise training in diabetic rats persist after three weeks of detraining

C Mostarda, A Rogow, ICM Silva, N Raquel… - Autonomic …, 2009 - Elsevier
Regarding all benefits of exercise training, a question remains: how long are these benefits
kept? This study evaluated the effect of 3-week detraining after 10 weeks of training in STZ …

Efeitos fisiológicos do treinamento físico em pacientes portadores de diabetes tipo 1

K De Angelis, DY Pureza, LJF Flores… - … de Endocrinologia & …, 2006 - SciELO Brasil
Insulinoterapia, atividade física regular e planejamento alimentar, em conjunto, consistem
na abordagem mais completa no tratamento de portadores de diabetes mellitus tipo 1 …

A comparison of anesthetic complications between diabetic and nondiabetic dogs undergoing phacoemulsification cataract surgery: a retrospective study

JAC Oliver, L Clark, F Corletto… - Veterinary …, 2010 - Wiley Online Library
Objective To compare the incidence of anesthetic complications in diabetic and nondiabetic
dogs undergoing general anesthesia and phacoemulsification cataract surgery. Procedure …

High intensity aerobic exercise training improves deficits of cardiovascular autonomic function in a rat model of type 1 diabetes mellitus with moderate hyperglycemia

KN Grisé, TD Olver, MW McDonald… - Journal of diabetes …, 2016 - Wiley Online Library
Indices of cardiovascular autonomic neuropathy (CAN) in experimental models of Type 1
diabetes mellitus (T1DM) are often contrary to clinical data. Here, we investigated whether a …