Innovations and advances in modelling and measuring pain in animals
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …
decade as a result of technological advancements, the continued dearth of translational …
Targeting translation: A review of preclinical animal models in the development of treatments for chemotherapy‐induced peripheral neuropathy
D White, M Abdulla, SB Park… - Journal of the …, 2023 - Wiley Online Library
Abstract Background and Aims The expanding use of chemotherapy in curative cancer
treatment has simultaneously resulted in a substantial and growing cohort of cancer …
treatment has simultaneously resulted in a substantial and growing cohort of cancer …
[HTML][HTML] Automated preclinical detection of mechanical pain hypersensitivity and analgesia
The lack of sensitive and robust behavioral assessments of pain in preclinical models has
been a major limitation for both pain research and the development of novel analgesics …
been a major limitation for both pain research and the development of novel analgesics …
Spinal neuropeptide Y Y1 receptor-expressing neurons are a pharmacotherapeutic target for the alleviation of neuropathic pain
TS Nelson, GP Sinha, DFS Santos… - Proceedings of the …, 2022 - National Acad Sciences
Peripheral nerve injury sensitizes a complex network of spinal cord dorsal horn (DH)
neurons to produce allodynia and neuropathic pain. The identification of a druggable target …
neurons to produce allodynia and neuropathic pain. The identification of a druggable target …
Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein
HIV-associated sensory neuropathies (HIV-SN) are prevalent in> 50% of patients aged over
45 years many of which report moderate to severe chronic pain. Previous preclinical studies …
45 years many of which report moderate to severe chronic pain. Previous preclinical studies …
Systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease-associated persistent pain
Burrowing behaviour is used to assess pain-associated behaviour in laboratory rodents. To
gain insight into how models of disease-associated persistent pain and analgesics affect …
gain insight into how models of disease-associated persistent pain and analgesics affect …
The history of pain measurement in humans and animals
JS Mogil - Frontiers in Pain Research, 2022 - frontiersin.org
Pain needs to be measured in order to be studied and managed. Pain measurement
strategies in both humans and non-human animals have varied widely over the years and …
strategies in both humans and non-human animals have varied widely over the years and …
[HTML][HTML] Duration of reduction in enduring stress-induced hyperalgesia via FKBP51 inhibition depends on timing of administration relative to traumatic stress exposure
BJ Wanstrath, SA McLean, Y Zhao, J Mickelson… - The journal of pain, 2022 - Elsevier
Chronic pain development is a frequent outcome of severe stressor exposure, with or
without tissue injury. Enduring stress-induced hyperalgesia (ESIH) is believed to play a …
without tissue injury. Enduring stress-induced hyperalgesia (ESIH) is believed to play a …
Role of mu opioid receptor (MOR) agonist efficacy as a determinant of opioid antinociception in a novel assay of pain-depressed behavior in female and male mice
SS Negus, HI Akbarali, M Kang, YK Lee… - Frontiers in Pain …, 2023 - frontiersin.org
Introduction Intermediate efficacy mu opioid receptor (MOR) agonists have potential to retain
analgesic effectiveness while improving safety, but the optimal MOR efficacy for effective …
analgesic effectiveness while improving safety, but the optimal MOR efficacy for effective …
Spinal cord injury in mice amplifies anxiety: A novel light-heat conflict test exposes increased salience of anxiety over heat
Spinal cord injury (SCI) predisposes individuals to anxiety and chronic pain. Anxiety-and
pain-like behavior after SCI can be tested in rodents, yet commonly used tests assess one …
pain-like behavior after SCI can be tested in rodents, yet commonly used tests assess one …