COVID-19 and metabolic disease: mechanisms and clinical management

C Steenblock, PEH Schwarz, B Ludwig… - The lancet Diabetes & …, 2021 - thelancet.com
Up to 50% of the people who have died from COVID-19 had metabolic and vascular
disorders. Notably, there are many direct links between COVID-19 and the metabolic and …

Is adipose tissue a reservoir for viral spread, immune activation, and cytokine amplification in coronavirus disease 2019?

PMD Ryan, NM Caplice - Obesity, 2020 - Wiley Online Library
Coronavirus disease 2019 (COVID‐19), the worst pandemic in more than a century, has
claimed> 125,000 lives worldwide to date. Emerging predictors for poor outcomes include …

Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis

SMM Aghili, M Ebrahimpur, B Arjmand… - International journal of …, 2021 - nature.com
Background Recent studies have shown that obesity is associated with the severity of
coronavirus disease (COVID-19). We reviewed clinical studies to clarify the obesity …

[HTML][HTML] Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity

RJ Henning - American journal of cardiovascular disease, 2021 - ncbi.nlm.nih.gov
Two billion people worldwide older than 18 years of age, or approximately 30% of the world
population, are overweight or obese. In addition, more than 43 million children under the …

The role of IL-6 in skin fibrosis and cutaneous wound healing

BZ Johnson, AW Stevenson, CM Prêle, MW Fear… - Biomedicines, 2020 - mdpi.com
The timely resolution of wound healing is critical for restoring the skin as a protective barrier.
The switch from a proinflammatory to a reparative microenvironment must be tightly …

Nutrition and frailty: opportunities for prevention and treatment

M Ni Lochlainn, NJ Cox, T Wilson, RPG Hayhoe… - Nutrients, 2021 - mdpi.com
Frailty is a syndrome of growing importance given the global ageing population. While frailty
is a multifactorial process, poor nutritional status is considered a key contributor to its …

[HTML][HTML] Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases

AL Cardoso, A Fernandes, JA Aguilar-Pimentel… - Ageing research …, 2018 - Elsevier
Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Mechanism of inflammatory response in associated comorbidities in COVID-19

TMC de Lucena, AF da Silva Santos… - Diabetes & Metabolic …, 2020 - Elsevier
Background and aims The outbreak of the new coronavirus, SARS-CoV-2, causes a
respiratory disease and individuals with pre-existing cardiometabolic disorders display …

Role of monocytes/macrophages in Covid-19 pathogenesis: implications for therapy

J Gómez-Rial, I Rivero-Calle, A Salas… - Infection and Drug …, 2020 - Taylor & Francis
cov-Abstract Emerging studies from SARS-CoV-2-infected patients indicate a preponderant
role of monocytes/macrophages in the pathogenesis of this viral infection, in a similar way to …

Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity

HE Kunz, CR Hart, KJ Gries, M Parvizi… - American Journal …, 2021 - journals.physiology.org
Obesity is accompanied by numerous systemic and tissue-specific derangements, including
systemic inflammation, insulin resistance, and mitochondrial abnormalities in skeletal …