Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that
are already known for use treating other diseases. The advantages of this are that several …

Rho GTPases are key molecular switches controlling the transduction of external signals to
cytoplasmic and nuclear effectors. In the last few years, the development of genetic and …

Abstract Acyl-CoA synthetase 4 (ACSL4) is an isoenzyme of the fatty acid ligase-coenzyme-
A family taking part in arachidonic acid metabolism and steroidogenesis. ACSL4 is involved …

Melanoma is a highly lethal cancer deriving from transformed dermal melanocytes. Early
diagnosed primary melanoma may be curable, but the cure-rate of more advanced stages is …

Fusion, proliferation, angiogenesis, immune tolerance, and tissue survival are some of the
critical functions involved in the physiological and pathological processes of placenta …

Telomere comprises the ends of eukaryotic linear chromosomes and is composed of G-rich
(TTAGGG) tandem repeats which play an important role in maintaining genome stability …

Telomeropathies involve a wide variety of infrequent genetic diseases caused by mutations
in the telomerase maintenance mechanism or the DNA damage response (DDR) system …

PIN1 is the only known enzyme capable of recognizing and isomerizing the phosphorylated
Serine/Threonine‑Proline motif. Through this mechanism, PIN1 controls diverse cellular …

The blood-brain barrier (BBB) constitutes an efficient organization of tight junctions that limits
the delivery of tumor to the brain. The principal tight junction protein in BBB is claudin-5 …

The process of carcinogenesis and its progression involves an intricate interplay between a
number of signaling networks, metabolic pathways and the microenvironment. These …