Targeting TGF-β signaling in cancer
Introduction: The transforming growth factor-β (TGF-β) signaling pathway has a pivotal role
in tumor suppression and yet, paradoxically, in tumor promotion. Functional context …
in tumor suppression and yet, paradoxically, in tumor promotion. Functional context …
A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF‐β signaling
KA Brown, JA Pietenpol… - Journal of cellular …, 2007 - Wiley Online Library
Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells,
and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to …
and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to …
TGF-β signaling in liver and gastrointestinal cancers
LH Katz, M Likhter, W Jogunoori, M Belkin, K Ohshiro… - Cancer letters, 2016 - Elsevier
Abstract Transforming Growth Factor-β (TGF-β) plays crucial and complex roles in liver and
gastrointestinal cancers. These include a multitude of distinct functions, such as maintaining …
gastrointestinal cancers. These include a multitude of distinct functions, such as maintaining …
Contextual regulation of TGF-β signaling in liver cancer
S Tu, W Huang, C Huang, Z Luo, X Yan - Cells, 2019 - mdpi.com
Primary liver cancer is one of the leading causes for cancer-related death worldwide.
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that signals through …
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that signals through …
[HTML][HTML] The roles of E3 ligases in Hepatocellular carcinoma
Z Yu, H Li, J Zhu, H Wang, X Jin - American journal of cancer …, 2022 - ncbi.nlm.nih.gov
Hepatocarcinogenesis is a complex multistep biological process involving genetic and
epigenetic alterations that are accompanied by activation of oncoproteins and inactivation of …
epigenetic alterations that are accompanied by activation of oncoproteins and inactivation of …
Comparative analysis of TGF-β/Smad signaling dependent cytostasis in human hepatocellular carcinoma cell lines
J Dzieran, J Fabian, T Feng, C Coulouarn, I Ilkavets… - PloS one, 2013 - journals.plos.org
Hepatocellular carcinoma (HCC) is a major public health problem due to increased
incidence, late diagnosis and limited treatment options. TGF-β is known to provide cytostatic …
incidence, late diagnosis and limited treatment options. TGF-β is known to provide cytostatic …
E3 ubiquitin ligases: key regulators of TGFβ signaling in cancer progression
Transforming growth factor β (TGFβ) is a secreted growth and differentiation factor that
influences vital cellular processes like proliferation, adhesion, motility, and apoptosis …
influences vital cellular processes like proliferation, adhesion, motility, and apoptosis …
Praja1 RING‐finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP‐43 aggregate formation
Transactivation response DNA‐binding protein of 43 kDa (TDP‐43) is a major constituent of
cytoplasmic aggregates in neuronal and glial cells in cases of amyotrophic lateral sclerosis …
cytoplasmic aggregates in neuronal and glial cells in cases of amyotrophic lateral sclerosis …
PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma
SY Huang, S Gong, Y Zhao, ML Ye, JY Li… - Nature …, 2024 - nature.com
Chemoresistance is a main reason for treatment failure in patients with nasopharyngeal
carcinoma, but the exact regulatory mechanism underlying chemoresistance in …
carcinoma, but the exact regulatory mechanism underlying chemoresistance in …
TGF-β signaling in onset and progression of hepatocellular carcinoma
NM Meindl-Beinker, K Matsuzaki, S Dooley - Digestive diseases, 2012 - karger.com
Transforming growth factor (TGF)-β is a central regulator in chronic liver disease,
contributing to all stages of disease progression from initial liver injury through inflammation …
contributing to all stages of disease progression from initial liver injury through inflammation …