Multigene panel tests for hereditary cancer syndromes are increasingly utilized in the care of
colorectal cancer (CRC) and polyposis patients. However, widespread availability of panels …

Purpose Genetic testing for breast cancer risk is evolving rapidly, with growing use of
multiple-gene panels that can yield uncertain results. However, little is known about the …

Background Precision oncology, using comprehensive biomarker testing (cBT) to inform
individual cancer diagnosis, prognosis and treatment, includes increasingly complex …

As genetics and genomics become part of mainstream Medicine, these advances have the
potential to reduce or exacerbate health disparities. Gaps in effective communication (where …

This article characterizes the opinions of patients and family members of patients
undergoing clinical genomic-based testing regarding the return of incidental findings from …

Effective communication, where all parties share a common understanding, is necessary to
realize the promise of Genomic Medicine. It is especially salient given the imperative to …

Precision medicine approaches disease treatment and prevention by taking patients'
individual variability in genes, environment, and lifestyle into account. Although the ideas …

Background Germline genome sequencing in childhood cancer precision medicine trials
may reveal pathogenic or likely pathogenic variants in cancer predisposition genes in more …

A great successof modern human genetics is the identification of specific genes that, when
altered, confer clinically recognized traits, such as cancer susceptibility, and enable …

Providers and patients encounter challenges related to the management of Variants of
Unknown Significance (VUS). A VUS introduces new counseling dilemmas for the …