[HTML][HTML] Ionizing radiation-induced circulatory and metabolic diseases
S Tapio, MP Little, JC Kaiser, N Impens… - Environment …, 2021 - Elsevier
Risks to health are the prime consideration in all human situations of ionizing radiation
exposure and therefore of relevance to radiation protection in all occupational, medical, and …
exposure and therefore of relevance to radiation protection in all occupational, medical, and …
Strategies for optimizing the response of cancer and normal tissues to radiation
Approximately 50% of all patients with cancer receive radiation therapy at some point during
the course of their treatment, and the majority of these patients are treated with curative …
the course of their treatment, and the majority of these patients are treated with curative …
Cardiac microvascular endothelial enhancement of cardiomyocyte function is impaired by inflammation and restored by empagliflozin
The positive findings of the EMPA-REG OUTCOME trial (Randomized, Placebo-Controlled
Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients …
Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients …
An inducible long noncoding RNA amplifies DNA damage signaling
Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but
mostly unknown functions. Here we demonstrate that lncRNAs guide the organismal DNA …
mostly unknown functions. Here we demonstrate that lncRNAs guide the organismal DNA …
Ionizing radiation-induced endothelial cell senescence and cardiovascular diseases
Y Wang, M Boerma, D Zhou - Radiation research, 2016 - meridian.allenpress.com
Exposure to ionizing radiation induces not only apoptosis but also senescence. While the
role of endothelial cell apoptosis in mediating radiation-induced acute tissue injury has been …
role of endothelial cell apoptosis in mediating radiation-induced acute tissue injury has been …
Individual response to ionizing radiation
N Foray, M Bourguignon, N Hamada - Mutation Research/Reviews in …, 2016 - Elsevier
The human response to ionizing radiation (IR) varies among individuals. The first evidence
of the individual response to IR was reported in the beginning of the 20th century …
of the individual response to IR was reported in the beginning of the 20th century …
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
PF Cheung, JJ Yang, R Fang, A Borgers… - Nature …, 2022 - nature.com
Immune evasion is indispensable for cancer initiation and progression, although its
underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known …
underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known …
Effects of ionizing radiation on the heart
M Boerma, V Sridharan, XW Mao, GA Nelson… - … Research/Reviews in …, 2016 - Elsevier
This article provides an overview of studies addressing effects of ionizing radiation on the
heart. Clinical studies have identified early and late manifestations of radiation-induced …
heart. Clinical studies have identified early and late manifestations of radiation-induced …
PPARγ-p53-mediated vasculoregenerative program to reverse pulmonary hypertension
JK Hennigs, A Cao, CG Li, M Shi, J Mienert… - Circulation …, 2021 - Am Heart Assoc
Rationale: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative
vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone …
vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone …
P53, GHRH, inflammation and cancer
N Barabutis, AV Schally, A Siejka - EBioMedicine, 2018 - thelancet.com
P53 is a transcription factor very often mutated in malignancies. It functions towards the
regulation of important cellular activities, such as cell cycle, senescence and apoptosis …
regulation of important cellular activities, such as cell cycle, senescence and apoptosis …