[HTML][HTML] Ionizing radiation-induced circulatory and metabolic diseases

S Tapio, MP Little, JC Kaiser, N Impens… - Environment …, 2021 - Elsevier
Risks to health are the prime consideration in all human situations of ionizing radiation
exposure and therefore of relevance to radiation protection in all occupational, medical, and …

Strategies for optimizing the response of cancer and normal tissues to radiation

EJ Moding, MB Kastan, DG Kirsch - Nature reviews Drug discovery, 2013 - nature.com
Approximately 50% of all patients with cancer receive radiation therapy at some point during
the course of their treatment, and the majority of these patients are treated with curative …

Cardiac microvascular endothelial enhancement of cardiomyocyte function is impaired by inflammation and restored by empagliflozin

RP Juni, DWD Kuster, M Goebel, M Helmes… - JACC: Basic to …, 2019 - jacc.org
The positive findings of the EMPA-REG OUTCOME trial (Randomized, Placebo-Controlled
Cardiovascular Outcome Trial of Empagliflozin) on heart failure (HF) outcome in patients …

An inducible long noncoding RNA amplifies DNA damage signaling

AM Schmitt, JT Garcia, T Hung, RA Flynn, Y Shen… - Nature …, 2016 - nature.com
Long noncoding RNAs (lncRNAs) are prevalent genes with frequently precise regulation but
mostly unknown functions. Here we demonstrate that lncRNAs guide the organismal DNA …

Ionizing radiation-induced endothelial cell senescence and cardiovascular diseases

Y Wang, M Boerma, D Zhou - Radiation research, 2016 - meridian.allenpress.com
Exposure to ionizing radiation induces not only apoptosis but also senescence. While the
role of endothelial cell apoptosis in mediating radiation-induced acute tissue injury has been …

Individual response to ionizing radiation

N Foray, M Bourguignon, N Hamada - Mutation Research/Reviews in …, 2016 - Elsevier
The human response to ionizing radiation (IR) varies among individuals. The first evidence
of the individual response to IR was reported in the beginning of the 20th century …

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression

PF Cheung, JJ Yang, R Fang, A Borgers… - Nature …, 2022 - nature.com
Immune evasion is indispensable for cancer initiation and progression, although its
underlying mechanisms in pancreatic ductal adenocarcinoma (PDAC) are not fully known …

Effects of ionizing radiation on the heart

M Boerma, V Sridharan, XW Mao, GA Nelson… - … Research/Reviews in …, 2016 - Elsevier
This article provides an overview of studies addressing effects of ionizing radiation on the
heart. Clinical studies have identified early and late manifestations of radiation-induced …

PPARγ-p53-mediated vasculoregenerative program to reverse pulmonary hypertension

JK Hennigs, A Cao, CG Li, M Shi, J Mienert… - Circulation …, 2021 - Am Heart Assoc
Rationale: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative
vascular disease are associated with DNA damage and impaired signaling of BMPR2 (bone …

P53, GHRH, inflammation and cancer

N Barabutis, AV Schally, A Siejka - EBioMedicine, 2018 - thelancet.com
P53 is a transcription factor very often mutated in malignancies. It functions towards the
regulation of important cellular activities, such as cell cycle, senescence and apoptosis …