Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin …
CA Bousman, JM Stevenson… - Clinical …, 2023 - Wiley Online Library
Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …
Complexities of CYP2D6 gene analysis and interpretation
A Gaedigk - International review of psychiatry, 2013 - Taylor & Francis
Abstract Cytochrome P450 2D6 (CYP2D6) plays an important role in the metabolism and
bioactivation of about 25% of clinically used drugs including many antidepressants …
bioactivation of about 25% of clinically used drugs including many antidepressants …
Prediction of CYP2D6 phenotype from genotype across world populations
A Gaedigk, K Sangkuhl, M Whirl-Carrillo, T Klein… - Genetics in …, 2017 - nature.com
Purpose: Owing to its highly polymorphic nature and major contribution to the metabolism
and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively …
and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively …
[HTML][HTML] Frequency of CYP2D6 alleles including structural variants in the United States
AL Del Tredici, A Malhotra, M Dedek, F Espin… - Frontiers in …, 2018 - frontiersin.org
The CYP2D6 gene encodes an enzyme important in the metabolism of many commonly
used medications. Variation in CYP2D6 is associated with inter-individual differences in …
used medications. Variation in CYP2D6 is associated with inter-individual differences in …
Challenges in CYP2D6 phenotype assignment from genotype data: a critical assessment and call for standardization
J Kevin Hicks, JJ Swen, A Gaedigk - Current drug metabolism, 2014 - ingentaconnect.com
The cytochrome P450 2D6 (CYP2D6) enzyme contributes to the metabolism and/or
bioactivation of approximately 25% of clinically used drugs. The CYP2D6 gene locus is …
bioactivation of approximately 25% of clinically used drugs. The CYP2D6 gene locus is …
Sequencing the CYP2D6 Gene: From Variant Allele Discovery to Clinical Pharmacogenetic Testing
CYP2D6 is one of the most studied enzymes in the field of pharmacogenetics. The CYP2D6
gene is highly polymorphic with over 100 catalogued star (*) alleles, and clinical CYP2D6 …
gene is highly polymorphic with over 100 catalogued star (*) alleles, and clinical CYP2D6 …
Differential regulation of CYP3A4 and CYP3A5 and its implication in drug discovery
Background: Cancer cells use several mechanisms to resist the cytotoxic effects of drugs,
resulting in tumor progression and invasion. One such mechanism capitalizes on the body's …
resulting in tumor progression and invasion. One such mechanism capitalizes on the body's …
Long‐read single molecule real‐time full gene sequencing of cytochrome P450‐2D6
ABSTRACT The cytochrome P450‐2D6 (CYP2D6) enzyme metabolizes∼ 25% of common
medications, yet homologous pseudogenes and copy number variants (CNVs) make …
medications, yet homologous pseudogenes and copy number variants (CNVs) make …
Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing
LH Cavallari, SL Van Driest, CA Prows, JR Bishop… - Genetics in …, 2019 - nature.com
Purpose A number of institutions have clinically implemented CYP2D6 genotyping to guide
drug prescribing. We compared implementation strategies of early adopters of CYP2D6 …
drug prescribing. We compared implementation strategies of early adopters of CYP2D6 …
Human cytochrome P450 epoxygenases: variability in expression and role in inflammation-related disorders
Beyond their contribution to the metabolism of xenobiotics, cytochrome P450 (CYP)
epoxygenases are actively involved in the metabolism of endogenous substances, like …
epoxygenases are actively involved in the metabolism of endogenous substances, like …