Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Liver metastases are commonly detected in a range of malignancies including colorectal
cancer (CRC), pancreatic cancer, melanoma, lung cancer and breast cancer, although CRC …

Inferring single-cell compositions and their contributions to global gene expression changes
from bulk RNA sequencing (RNA-seq) datasets is a major challenge in oncology. Here we …

The tumor microenvironment (TME) is made up of cells and extracellular matrix (non-cellular
component), and cellular components include cancer cells and non-malignant cells such as …

Bone metastases are a frequent and severe complication of advanced-stage cancers. Breast
and prostate cancers, the most common malignancies in women and men, respectively …

The co‐occurrence of cancer and heart failure (HF) represents a significant clinical
drawback as each disease interferes with the treatment of the other. In addition to shared …

Recent developments in nanotechnology have brought new approaches to cancer
diagnosis and therapy. While enhanced permeability and retention effect promotes nano …

Lymph node metastasis, the leading cause of mortality in esophageal squamous carcinoma
(ESCC) with a highly complex tumor microenvironment, remains underexplored. Here, the …

Metastasis is a major contributor to cancer-associated deaths. It involves complex
interactions between primary tumorigenic sites and future metastatic sites. Accumulation …

Recent advances in the field of immunotherapy have profoundly opened up the potential for
improved cancer therapy and reduced side effects. However, the tumor microenvironment …