Mass spectrometry-based biomolecular analyses have become permanent fixtures of
academic, industrial, and clinical research settings. The rise in utilization of mass …

Imaging mass spectrometry (IMS) technologies are capable of mapping a wide array of
biomolecules in diverse cellular and tissue environments. IMS has emerged as an essential …

In this work, we pioneered a combination of ultralow flow (ULF) high-efficiency ultranarrow
bore monolithic LC columns coupled to MS via a high-field asymmetric waveform ion …

Post-translational modifications (PTMs) on intact histones play a major role in regulating
chromatin dynamics and influence biological processes such as DNA transcription …

Although there has been a surge in popularity of differential mobility spectrometry (DMS)
within analytical workflows, determining separation conditions within the DMS parameter …

Unambiguous identification of distinct proteoforms and their biological functions is a
significant analytical challenge due to the many combinations of post-translational …

α-Synuclein is an intrinsically disordered protein that plays a critical role in the pathogenesis
of neurodegenerative disorders, such as Parkinson's disease. Proteomics studies of human …

Continuing advances in proteomics highlight the ubiquity and biological importance of
proteoforms─ proteins with varied sequence, splicing, or distribution of post-translational …

The presence of solvent vapor in a differential mobility spectrometry (DMS) cell creates a
microsolvating environment that can mitigate complications associated with field-induced …

The experimental determination of ion-neutral collision cross sections (CCSs) is generally
confined to ion mobility spectrometry (IMS) technologies that operate under the so-called …