[HTML][HTML] Histological scores in patients with inflammatory bowel diseases: the state of the art

E Vespa, F D'Amico, M Sollai, M Allocca… - Journal of Clinical …, 2022 - mdpi.com
The histological assessment has been advocated as a detailed and accurate measure of
disease activity in inflammatory bowel diseases (IBD). In ulcerative colitis (UC), histological …

[HTML][HTML] Emerging strategy towards mucosal healing in inflammatory bowel disease: what the future holds?

M Wang, J Shi, C Yu, X Zhang, G Xu, Z Xu… - Frontiers in …, 2023 - frontiersin.org
For decades, the therapeutic goal of conventional treatment among inflammatory bowel
disease (IBD) patients is alleviating exacerbations in acute phase, maintaining remission …

Deep learning models capture histological disease activity in Crohn's disease and ulcerative colitis with high fidelity

D Rymarczyk, W Schultz, A Borowa… - Journal of Crohn's …, 2024 - academic.oup.com
Abstract Background and Aims Histological disease activity in inflammatory bowel disease
[IBD] is associated with clinical outcomes and is an important endpoint in drug development …

Artificial intelligence and endo-histo-omics: new dimensions of precision endoscopy and histology in inflammatory bowel disease

M Iacucci, G Santacroce, I Zammarchi… - The Lancet …, 2024 - thelancet.com
Integrating artificial intelligence into inflammatory bowel disease (IBD) has the potential to
revolutionise clinical practice and research. Artificial intelligence harnesses advanced …

[HTML][HTML] Histologic activity in inflammatory bowel disease and risk of serious infections: A nationwide study

K Mårild, J Söderling, J Axelrad, J Halfvarson… - Clinical …, 2024 - Elsevier
Background & Aims Individuals with inflammatory bowel disease (IBD) are at increased risk
of serious infections, but whether this risk varies by histologic disease activity is unclear …

To STRIDE or not to STRIDE: a critique of “treat to target” in Crohn´ s disease

KR Herrlinger, EF Stange - Expert Review of Gastroenterology & …, 2023 - Taylor & Francis
Introduction The STRIDE consensus suggested to focus on mucosal healing, based on
biomarkers and endoscopy, in addition to clinical endpoints as treatment target. This …

Histologic assessments in ulcerative colitis: The evidence behind a new endpoint in clinical trials

RK Pai, G D'Haens, T Kobayashi… - Expert Review of …, 2024 - Taylor & Francis
Introduction Treatment goals for ulcerative colitis (UC) are evolving from the achievement of
clinical remission to more rigorous goals defined by endoscopic and histologic healing …

[HTML][HTML] Inflammatory Bowel Diseases: Does One Histological Score Fit All?

V Villanacci, R Del Sordo, TL Parigi, G Leoncini… - Diagnostics, 2023 - mdpi.com
Mucosal healing (MH) is the main treatment target in ulcerative colitis (UC) and Crohn's
disease, and it is defined by the combination of complete endoscopic and histologic …

[HTML][HTML] Effects of mirikizumab on histologic resolution of Crohn's disease in a randomized controlled phase 2 trial

F Magro, M Protic, G De Hertogh, LS Chan… - Clinical …, 2023 - Elsevier
Background & Aims Histologic evaluation of mucosal healing in Crohn's disease is an
evolving treatment target. We evaluated histologic outcomes for mirikizumab efficacy and …

[HTML][HTML] Histological remission in inflammatory bowel disease and risk of adverse pregnancy outcomes: A nationwide study

K Mårild, J Söderling, O Stephansson, J Axelrad… - …, 2022 - thelancet.com
Background Inflammatory bowel disease (IBD) has been linked to adverse pregnancy
outcomes, but it is unclear how risks vary by histological activity. Methods We performed a …