Tripartite motif containing-21 (TRIM21), an E3 ubiquitin ligase, was initially found to be
involved in antiviral responses and autoimmune diseases. Recently studies have reported …

Eukaryotic stress granules (SGs) are highly dynamic assemblies of untranslated mRNAs
and proteins that form through liquid-liquid phase separation (LLPS) under cellular stress …

Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic
calcification and pathological calcified osteoarthritis and in wound repair of the skeletal …

Constructive achievements in the field of nanobiotechnology and their translation into
clinical course have led to increasing attention towards evaluation of their use for treatment …

Abstract Background Sec23 homolog A (SEC23A), a core component of coat protein
complex II (COPII), has been reported to be involved in several cancers. However, the role of …

Despite the diverse roles of tripartite motif (Trim)-containing proteins in the regulation of
autophagy, the innate immune response, and cell differentiation, their roles in skeletal …

The discovery and application of small molecules is one of the practical strategies of safe
osteogenic drugs. The small molecule CHIR99021 (C91) is a highly specific, safe, and most …

Triple-negative breast cancer (TNBC) cells are in a more hypoxic and starved state than non-
TNBC cells, which makes TNBC cells always maintain high autophagy levels. Emerging …

Fluid shear stress (FSS) facilitates bone remodeling by regulating osteogenic differentiation,
and extracellular matrix maturation and mineralization. However, the underlying molecular …

Protein tyrosine phosphatase receptor type C (PTPRC) is reported to function as an
oncogenic role in various cancer. However, the studies on the roles of PTPRC in …