Antigen presentation by major histocompatibility complex (MHC) proteins is essential for
adaptive immunity. Prior to presentation, peptides need to be generated from proteins that …

Post-translational modification (PTM) of antigens provides an additional source of
specificities targeted by immune responses to tumors or pathogens, but identifying antigen …

A growing number of associations between adverse drug reactions and alleles of the human
leukocyte antigen (HLA) genes are now known. Although several models have been …

Human leukocyte antigen (HLA) class I molecules generally present peptides (p) of 8 to 11
amino acids (aa) in length. Although an increasing number of examples with lengthy (> 11 …

Class I HLAs generally present peptides of 8–10 aa in length, although it is unclear whether
peptide length preferences are affected by HLA polymorphism. In this study, we investigated …

The HLA‐E locus encodes a nonclassical class Ib molecule that serves many immune
functions from inhibiting NK cells to activating CTLs. Structural analysis of HLA‐E/NKG2A …

Human leukocyte antigen (HLA)-I molecules generally bind short peptides (8–10 amino
acids), although extended HLA-I restricted peptides (> 10 amino acids) can be presented to …

Human leukocyte antigen (HLA)-E molecules are potent inhibitors of NK cell-mediated
killing. Low in polymorphisms, two alleles are widely expressed among diverse populations …

The genetic polymorphism that has the greatest impact on immune control of human
immunodeficiency virus (HIV) infection is expression of HLA-B* 57. Understanding of the …

Major histocompatibility complex (MHC) class I proteins are expressed on the cell surface
where they present foreign and self-peptides to effector cells of the immune system. While …