Human embryogenesis is hallmarked by two phases of yolk sac development. The primate
hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a …

Megakaryocytes are hematopoietic cells, which are responsible for the production of blood
platelets. The traditional view of megakaryopoiesis describes the cellular journey from …

The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the
inability to identify HSCs as they emerge and mature at different haematopoietic sites. Here …

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the
developing embryo but remains ill-defined in humans. We therefore assembled a …

Tracing the emergence of the first hematopoietic stem cells (HSCs) in human embryos,
particularly the scarce and transient precursors thereof, is so far challenging, largely due to …

Through their oxygen delivery function, red blood cells are pivotal to the healthy existence of
all vertebrate organisms. These cells are required during all stages of life—embryonic, fetal …

Haematopoietic stem cells (HSCs) emerge during embryogenesis and give rise to the adult
haematopoietic system. Understanding how early haematopoietic development occurs is of …

Stem cells are currently in the news for two reasons: the successful cultivation of human
embryonic stem cell lines and reports that adult stem cells can differentiate into …

Human mesenchymal stem/progenitor cells (MSCs) have been identified in adult bone
marrow, but little is known about their presence during fetal life. MSCs were isolated and …

Microglial cells are thought to colonize the human cerebrum between the 4th and 24th
gestational weeks. Rodent studies have demonstrated that these cells originate from yolk …