The incidence of diabetes mellitus is approaching global epidemic proportions and should
be considered a major health-care problem of modern societies in the twenty-first century …

Peripheral nerve injury disrupts the normal functions of sensory and motor neurons by
damaging the integrity of axons and Schwann cells. In contrast to the central nervous …

Previous anti-inflammatory strategies against sepsis, a leading cause of death in hospitals,
had limited efficacy in clinical trials, in part because they targeted single cytokines and the …

The medial prefrontal cortex (mPFC) is a brain region involved in the affective components
of pain and undergoes plasticity during the development of chronic pain. Dopamine (DA) is …

Background Neuropathic pain is experienced worldwide by patients suffering from nerve
injuries, infectious or metabolic diseases or chemotherapy. However, the treatment options …

Satellite glial cells (SGCs) are homeostatic cells enveloping the somata of peripheral
sensory and autonomic neurons. A wide variety of neuronal stressors trigger activation of …

The dynamic expansions and contractions of the microglia population in the central nervous
system (CNS) to achieve homeostasis are likely vital for their function. Microglia respond to …

The prefrontal cortex (PFC) is a complex brain region that regulates diverse functions
ranging from cognition, emotion and executive action to even pain processing. To decode …

Peripheral nerve injury sensitizes a complex network of spinal cord dorsal horn (DH)
neurons to produce allodynia and neuropathic pain. The identification of a druggable target …

Neuropathic pain arises as a consequence of a lesion or a disease affecting the
somatosensory system. This syndrome results from maladaptive changes in injured sensory …