Abstract Alpha‐1‐antitrypsin (AAT) deficiency (AATD) is a genetic disease, caused by
mutation of the AAT gene. Accumulation of mutated AAT protein aggregates in hepatocytes …

α1-Antitrypsin (AAT) deficiency is an underrecognized genetic condition that affects
approximately 1 in 2,000 to 1 in 5,000 individuals and predisposes to liver disease and early …

Purpose—The aim of this updated statement is to provide comprehensive and evidence-
based recommendations for management of patients with unruptured intracranial …

Summary α1-antitrypsin deficiency is a genetic disorder that affects about one in 2000–5000
individuals. It is clinically characterised by liver disease and early-onset emphysema …

A 60-year-old white man presents for evaluation of progressive dyspnea. He is a former
smoker with a 20-pack-year smoking history and a 10-year history of chronic obstructive …

The current study focuses on developing estimates of the numbers of individuals carrying
the two most common deficiency alleles, PI* S and PI* Z, for α1-antitrypsin deficiency (AT-D) …

Alpha 1-antitrypsin deficiency is an inherited metabolic disorder that predisposes the
affected individual to chronic pulmonary disease, in addition to chronic liver disease …

Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. The typical
pulmonary manifestation is chronic obstructive pulmonary disease and emphysema. Severe …

Background Preterm birth is defined as live birth before 37 completed weeks of pregnancy,
and it is a major problem worldwide. The molecular mechanisms that lead to onset of …

COPD is a clinically heterogeneous syndrome characterized by injury to airways, airspaces,
and lung vasculature and usually caused by tobacco smoke and/or air pollution exposure …