Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …

Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …

More than 800 million people suffer from kidney disease, yet the mechanism of kidney
dysfunction is poorly understood. In the present study, we define the genetic association with …

It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can
directly infect human kidney, thus leading to acute kidney injury (AKI). Here, we perform a …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Liver fibrosis is a progression of chronic liver disease, which lacks effective therapies in the
world. Attractively, more and more evidences show that natural products are safe and …

Inflammation triggers pulmonary vascular remodelling. Ferroptosis, a nonapoptotic form of
cell death that is triggered by iron-dependent lipid peroxidation and contributes to the …

Abstract Background Approximately 8–9% of the world's population is affected by
autoimmune diseases, and yet the mechanism of autoimmunity trigger is largely …

Acute kidney injury (AKI) is a common clinical state resulting from pathogenic conditions
such as ischemic and toxic insults. The pathophysiology of AKI shares common pathogenic …

Apoptotic cell death is usually a response to the cell's microenvironment. In the kidney,
apoptosis contributes to parenchymal cell loss in the course of acute and chronic renal …