Viruses intricately interact with and modulate cellular membranes at several stages of their
replication, but much less is known about the role of viral lipids compared to proteins and …

Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

During the late phase of HIV type 1 (HIV-1) replication, newly synthesized retroviral Gag
proteins are targeted to the plasma membrane of most hematopoietic cell types, where they …

HIV-1 particle production occurs in a series of steps promoted by the viral Gag protein.
Although it is well established that assembly and release take place at the plasma …

A critical early event in the HIV type 1 (HIV-1) particle assembly pathway is the targeting of
the Gag protein to the site of virus assembly. In many cell types, assembly takes place …

Recently proposed models that have gained wide acceptance posit that HIV-1 virion
morphogenesis is initiated by targeting the major structural protein (Gag) to late endosomal …

Membrane binding of Gag, a crucial step in HIV-1 assembly, is facilitated by bipartite signals
within the matrix (MA) domain: N-terminal myristoyl moiety and the highly basic region …

Budding of lentiviruses occurs at the plasma membrane, but the preceding steps involved in
particle assembly are poorly understood. Since the Gag polyprotein mediates virion …

The assembly of infectious human immunodeficiency virus (HIV) requires that Gag transport
and oligomerization be coordinated with its association with other viral proteins, viral RNAs …

Human immunodeficiency virus type 1 (HIV-1) particle assembly mediated by the viral
structural protein Gag occurs predominantly on the plasma membrane (PM). Although it is …